Cancer: Emerging Hallmarks and Enabling Characteristics

Cancer: Emerging Hallmarks and Enabling Characteristics ... Over the past decade, two new hallmarks have emerged: reprograming of cellular energy ... Skiptocontent Cancer:EmergingHallmarksandEnablingCharacteristics Thehallmarksofcancer–aphraseoriginallycoinedbyDougHanahanandBobWeinberg–comprisesixbiologicalcapabilitiesacquiredduringcancerdevelopment:sustainedproliferativesignaling,theevasionofgrowthsuppression,resistancetocelldeath,replicativeimmortality,angiogenesis,andinvasionandmetastasis.Overthepastdecade,twonewhallmarkshaveemerged:reprogramingofcellularenergymetabolismandtheevasionofimmunedestruction.Thesehallmarksaredrivenandsustainedbygenomicinstabilityandinflammation.Thissession,encompassingseventalks,willaddressmanyofthesehallmarksandenablingcharacteristics,agreaterunderstandingofwhichiscentraltoimproveddiagnostic,preventativeandtherapeuticapproachestocancer. Co-Chairs:NiallHowlett(RI),SherineElsawa(NH).MiniKeynote:MaryJoTurk(NH) 9:00am–9:05am Introduction NiallHowlett,PhD.PIMARC/U*STAR.UniversityofRhodeIsland,Professor,CellandMolecularBiology. SherineElsawa,PhD,NH-COBRECenterforIntegratedBiomedical&BioengineeringResearch(CIBBR).UniversityofNewHampshire,AssociateProfessor,Molecular,CellularandBiomedicalSciences. 9:05am–9:30am ResidentmemoryTcellresponsestocancer. MaryJoTurk,PhD.TheGeiselSchoolofMedicineatDartmouth,O.RossMcIntyre,M.D.Professor,NorrisCottonCancerCenter 9:30am–9:50am ImmunotherapyoptionsforPediatricAcuteMyelogenousLeukemia:Fromtargetidentificationtoclinicaltrial. SonaliBarwe,PhD.AlfredI.duPontHospitalforChildren(DE),SeniorResearchScientist,CancerModelingLaboratory  9:50am–10:10am Molecularpredictorsofcentralnervoussystemrecurrenceinaggressivelymphomas. AdamJ.Olszewski,MD.LifespanCancerInstituteatRhodeIslandHospital.AlpertMedicalSchoolofBrownUniversityAssociateProfessorofMedicine 10:10am–10:30am NovelroleforGLI2inmalignantBcellsandthetumormicroenvironment. SherineElsawa,PhD.NH-COBRECenterforIntegratedBiomedical&BioengineeringResearch(CIBBR). UniversityofNewHampshire,AssociateProfessorImmunology,Molecular,CellularandBiomedicalSciences  10:30am–10:50am Developmentandimplementationofapediatriconcologygenomicsprogram:afocusonleukemiasandthedevelopmentofnextgenerationsequencingtechniques. ErinCrowgey,PhD.DirectorofMedicalBioinformatics,NemoursChildren’sHospital(DE) AlfredI.duPontHospitalforChildrenNEMOURS/DE-CTRACCELResearchScientist 10:50am–11:10am RoleofSTAT3inovariancancer. SarahWalker,PhD.UniversityofNewHampshireAssistantProfessor,Molecular,CellularandBiomedicalSciences  11:10am–11:30am PIM1kinase:Anoveltargetinrenalcellcarcinoma. SheldonHolder,MD,PhD,BrownUniversityandLifespanCancerInstitute(LCI),AssistantProfessorofPathologyandLaboratoryMedicine Postnavigation PreviouspostNextpost ConnectApplyTourGive