陳炳宏副教授(Bing-Hung Chen) - 高雄醫學大學生物科技學系

研究肥大細胞去顆粒作用的分子調控機制：. 肥大細胞受到過敏原與IgE的刺激後，會將細胞質內的分泌型顆粒(secretory granules, SGs)經由胞吐 ... 繁體中文 English   搜尋... Menu 首頁Home 系學務訊息即時學系訊息.演講通知.作業考訊.工讀招募...等訊息通知(臉書) 活動剪影即時學系訊息.演講通知.作業考訊.工讀招募...等訊息通知(臉書) 系學生會即時學系訊息.演講通知.作業考訊.工讀招募...等訊息通知(臉書) 共用儀器預約 斑馬魚核心實驗室 登入 [僅限有發佈公告權限之註冊作者] 帳號 密碼 記得我 登入 首頁學系成員陳炳宏副教授(Bing-HungChen) 陳炳宏副教授(Bing-HungChen)   聯絡方式 辦公室:第一教學大樓N1023室 實驗室:第一教學大樓N1020室 電話:(07)3121101ext.2676 傳真:(07)3125339 電子郵件: [email protected] 其他個人網頁: 實驗室部落格(暫停維護) 臉書  學經歷 中山醫學大學醫事技術學系學士(1990) 美國維吉尼亞聯邦州立大學臨床實驗科學研究所碩士(1995) 美國維吉尼亞聯邦州立大學微生物與免疫學研究所博士(2001) 美國維吉尼亞聯邦州立大學微生物與免疫學研究所博士後研究(2001-2002) 國立清華大學生命科學院博士後研究(2002-2003) 高雄醫學大學蛋白質體中心學術合作組組長(2004-2006) 高雄醫學大學生物科技學系系主任(2012/08-2015/07) 主負責授課科目 生物科技導論 生物科技實驗 微生物學 免疫學 書報討論 專題研究 研究興趣 過敏與非過敏性發炎反應的分子生物學與細胞學的調控機制 抗過敏與抗發炎藥物之篩選與開發 肥大細胞與巨噬細胞之訊息傳遞機制研究 細胞脫顆粒作用調控   MechanisticRegulationofAllergicInflammatoryResponsesinMastCells 由於工業化以及飲食西化的影響，第一型即發型過敏性疾病的罹患率有逐年增加的趨勢。

此類過敏反應的成因，主要是由過敏原(如:花粉、塵蟎、花生、甲殼類海鮮、寵物皮屑等)所誘發B淋巴球製造的免疫球蛋白E(IgE)，結合與促進肥大細胞或嗜鹼性球活化所造成的免疫疾病。

研究發現，經由活化Th2淋巴細胞或是其他發炎細胞(如:巨噬細胞)所分泌的細胞激素亦能直接或間接地造成過敏反應症狀的惡化。

目前臨床上常用的治療過敏方法，包括給予病患症狀舒緩藥劑(如:抗組織胺)、類固醇、以及新開發的抗IgE單株抗體，然而這些療法都各有其侷限或不足之處。

因此，本實驗室之主要研究方向為了解肥大細胞的活化機制，期望可以探索與開發具有抑制過敏性發炎的新型製劑。

           實驗室研究方向 調控過敏與發炎性免疫反應的分子生物學與細胞學機制 抗過敏與抗發炎藥物之篩選與開發 白血球訊息傳遞機制研究 設計與開發具醫療潛力的融合蛋白質   MechanisticRegulationofAllergicInflammatoryResponsesinMastCells 由於工業化以及飲食西化的影響，第一型即發型過敏性疾病的罹患率有逐年增加的趨勢。

此類過敏反應的成因，主要是由過敏原(如:花粉、塵蟎、花生、甲殼類海鮮、寵物皮屑等)所誘發B淋巴球製造的免疫球蛋白E(IgE)，結合與促進肥大細胞或嗜鹼性球活化所造成的免疫疾病。

研究發現，經由活化Th2淋巴細胞或是其他發炎細胞(如:巨噬細胞)所分泌的細胞激素亦能直接或間接地造成過敏反應症狀的惡化。

目前臨床上常用的治療過敏方法，包括給予病患症狀舒緩藥劑(如:抗組織胺)、類固醇、以及新開發的抗IgE單株抗體，然而這些療法都各有其侷限或不足之處。

因此，本實驗室之主要研究方向為了解肥大細胞的活化機制，期望可以探索與開發具有抑制過敏性發炎的新型製劑。

    篩選新的抗過敏成份： 近年來，從天然食用與藥用植物中開發新的抗過敏成分已經逐漸受到重視。

我們利用囓齒類RBL-2H3與人類KU812肥大細胞株為篩選平台，分析不同的植物萃取物是否可以抑制這些細胞株因過敏原/IgE刺激所造成的活化現象(如:去顆粒化作用、胞內鈣離子變化、細胞激素基因表現等)，以用來當做評估其抗過敏潛力的指標。

研究肥大細胞去顆粒作用的分子調控機制： 肥大細胞受到過敏原與IgE的刺激後，會將細胞質內的分泌型顆粒(secretorygranules,SGs)經由胞吐作用(exocytosis)，將其中的各類型致敏性媒介物(例如:TNFalpha,MCP-1,IL-4)排放到胞外，因而導致過敏症狀的發生。

肥大細胞的胞吐作用又稱為去顆粒作用(degranulation)。

目前研究顯示，影響去顆粒作用的關鍵因子，包括了胞內鈣離子濃度以及分泌型顆粒能否與細胞膜進行融合。

此融合過程中，需要SGs與細胞膜上的不同蛋白質分子共同組成SNARE複合體(如:VAMP,SNAP,syntaxin)；此外，SGs上的鈣離子偵測蛋白(如:synaptotagmin)在促進融合的過程也扮演著重要的調控角色。

目前，我們有興趣研究人類與小鼠的肥大細胞株在去顆粒過程中，SNARE複合物的形成與調控上的差異、參與肥大細胞去顆粒作用的SNARE複合物形成之分子調控機制。

  期刊論文[近期發表論文(隨時更新): Google學術搜尋](更新日期:2020.12.23) ProductionofachimericformofCD23thatisoligomericandblocksIgEbindingtotheFcepsilonRI.KellyAE,ChenBH,WoodwardEC,ConradDH. J.Immunol. 1998;161:6696-6704.(PMID:9862699) NecessityofthestalkregionforimmunoglobulinEinteractionwithCD23.ChenBH,MaC,CavenTH,Chan-LiY,BeavilA,BeavilR,GouldH,ConradDH. Immunology 2002;107:373-381.(PMID:12423314) TemperatureeffectonIgEbindingtoCD23versusFcepsilonRI.ChenBH,KilmonMA,MaC,CavenTH,Chan-LiY,ShelburneAE,TombesRM,RoushE,ConradDH. J.Immunol. 2003;170:1839-1845.(PMID:12574349) Propertiesofhumanandrabbitcytosolicserinehydroxymethyltransferasearechangedbysinglenucleotidepolymorphicmutations.FuTF,HuntS,SchirchV,SafoMK,andChenBH. Arch.Biochem.Biophys. 2005;442:92-101.(PMID:16137637) Cloning,expression,purification,andcharacterizationofzebrafishcytosolicserinehydroxymethyltransferase.ChangWN,TsaiJN,ChenBH,FuTF. ProteinExpr.Purif. 2006;46:212-220.(PMID:16242955) Characterizationofchondroitinsulfateanditsinterpenetratingpolymernetworkhydrogelsforsustained-drugrelease.WangSC,ChenBH,WangLF,ChenJS. Int.J.Pharm. 2007;329:103-109.(PMID:16996709) Serinehydroxymethyltransferaseisoformsaredifferentiallyinhibitedbyleucovorin:characterizationandcomparisonofrecombinantzebrafishserinehydroxymethyltransferases.ChangWN,TsaiJN,ChenBH,HuangHS,FuTF. DrugMetab.Dispos. 2007;35(11):2127-2137.(PMID:17664250) TypeIIFNinducedIL1-RaexpressioninhepatocytesismediatedbyactivatingSTAT6throughtheformationofSTAT2:STAT6heterodimer.WanL,LinCW,LinYJ,SheuJJ,ChenBH,LiaoCC,TsaiY,LinWY,LaiCH,TsaiFJ. J.CellMol.Med. 2008;12(3):876-888.(PMID:18494930) Characterizationandcomparativestudiesofzebrafishandhumanrecombinantdihydrofolatereductases---Inhibitionbyfolicacidandpolyphenols.KaoTT,WangKC,ChangWN,LinCY,ChenBH,WuHL,ShiGY,TsaiJN,FuTF. DrugMetab.Dispos. 2008;36(3):508-516.(PMID:18056255) Poly(ethyleneimine)-g-chitosanusingEX-810asaspacerfornonviralgenedeliveryvectors.LouYL,PengYS,ChenBH,WangLF,LeongKW. J.BiomedMaterResA. 2009;15;88(4):1058-68.(PMID:18404706) Synthesisofcalciumphosphatesandporoushydroxyapatitebeadspreparedbyemulsionmethod.ChenBH,ChenKI,HoML,ChenHN,WangCK. MaterialsChemistryandPhysics 2009;113:365-371. Puerariaeradixisoflavonesandtheirmetabolitesinhibitgrowthandinduceapoptosisinbreastcancercells.LinYJ,HouYC,LinCH,HsuYA,SheuJJ,LaiCH,ChenBH,LeeChaoPD,WanL,TsaiFJ. Biochem.Biophys.Res.Commun. 2009;378(4):683-8.(PMID:19013426) AntiallergicpotentialonRBL-2H3cellsofsomephenolicconstituentsofZingiberofficinale(Ginger).ChenBH,WuPY,ChenKM,FuTF,WangHM,ChenCY. J.Nat.Prod. 2009;72,950-53.(PMID:19271742) AssociationoftheLumicangenefunctional3'UTRpolymorphismwithhighmyopia.LinHJ,KungYJ,LinYJ,SheuJJ,ChenBH,LanYC,LaiCH,ShuYA,WanL,TsaiFJ. Invest.Ophthalmol.Vis.Sci. 2010;51(1):96-102.(PMID:19643966) GrapeseedextractinhibitsthegrowthandpathogenicityofStaphylococcusaureusbyinterferingwithdihydrofolatereductaseactivityandfolate-mediatedone-carbonmetabolism.KaoTT,TuHC,ChangWN,ChenBH,ShiYY,ChangTC,FuTF. Int.J.FoodMicrobiol. 2010;30,141(1-2):17-27.(PMID:20483185) p38MAPKandNF-kappaBpathwaysareinvolvedinnaphtho[1,2-b]furan-4,5-diooneinducedanti-proliferationandapoptosisofhumanhepatomacells.ChiuCC,ChenJY,LinKL,HuangCJ,LeeJC,ChenBH,ChenWY,LoYH,ChenYL,TsengCH,ChenYL,LinSY. CancerLett. 2010;295(1):92-99.(PMID:20350781) AdditiveeffectsofC(2)-ceramideonpaclitaxel-inducedprematuresenescenceofhumanlungcancercells.ChenJY,HwangCC,ChenWY,LeeJC,FuTF,FangK,ChuYC,HuangYL,LinJC,TsaiWH,ChangHW,ChenBH*,ChiuCC*. LifeSci. 2010;87(11-12):350-7. BetelquidextractpromotesoralcancercellmigrationbyactivatingamuscarinicM4receptor-mediatedsignalingcascadeinvolvingSFKsandERK1/2.ChiuCC*,ChenBH*,HourTC,ChiangWF,WuYJ,ChenCY,ChenHR,ChanPT,LiuSY,ChenJY. BiochemBiophysResCommun. 2010;399(1):60-5. Versatilephosphoramidationreactionsfornucleicacidconjugationswithpeptides,proteins,chromophores,andbiotinderivatives.WangTP,ChiouYJ,ChenY,WangEC,HwangLC,ChenBH,ChenYH,KoCH. BioconjugChem. 2010;21(9):1642-55. CD23sheddaseADisintegrinAndMetallo-proteinase10(ADAM10)isalsorequiredforCD23sortingintoBcellderivedexosomes.MathewsJ,GibbD,ChenBH,ScherleP,ConradDH. J.BiologicalChem. 2010;285(48):37531-41. ZebrafishSp1-likeproteinisstructurallyandfunctionallycomparabletohumanSp1.LinCJ,HsiaoTH,ChungYS,ChangWN,YehTM,ChenBH,TuTF. ProteinExpr.Purif. 2011;76(1):36-43. Anoveltargetingmodalityforrenalcellcarcinoma:humanosteocalcinpromoter-mediatedgenetherapysynergisticallyinducedbyvitaminCandvitaminD3.JohnsonNA*,ChenBH*,SungSY,LiaoCH,LiaoCH,HsiaoWC,ChungWK,HsiehCL. J.GeneMed. 2010;12(11):892-903. (-)-AnonaineinducesDNAdamageandinhibitsgrowthandmigrationofhumanlungcarcinomaH1299cells.ChenBH,ChangHW,HuangHM,ChongIW,ChenJS,ChenCY,WangHM. J.Agric.FoodChem. 2011;59(6):2284-90. ANovelInteractionBetweenInterferon-InducibleProteinp56andRibosomalProteinL15inGastricCancerCells.HsuYA,LinHJ,SheuJJ,ShiehFK,ChenSY,LaiCH,TsaiFJ,WanL*,ChenBH*. DNACellBiology 2011;30(9):671-9. Anti-allergicactivityofgrapeseedextract(GSE)onRBL-2H3mastcells.ChenBH*,HungMH,ChenYF,ChangHW,YuML,WanL,TsaiFJ,WangTP,FuTF,ChiuCC*. FoodChem. 2012;132(2),968-74.(WOS:000300475800041) Biologicalpropertiesofacidiccosmeticwaterfromseawater. LiaoWT,HuangTS,ChiuCC,PanJL,LiangSS,ChenBH,ChenSH,LiuPL,WangHC,WenZH,WangHM,HsiaoSW. IntJMolSci.2012;13(5):5952-71. Methotrexate-induceddecreaseinembryonic5-methyl-tetrahydrofolateisirreversiblewithleucovorinsupplementation. KaoTT,LeeGH,FuCC,ChenBH,ChenLT,FuTF. Zebrafish.2013;10(3):326-37. Folatedeficiency-inducedoxidativestresscontributestoneuropathyinyoungandagedzebrafish--implicationinneuraltubedefectsandAlzheimer'sdiseases. KaoTT,ChuCY,LeeGH,HsiaoTH,ChengNW,ChangNS,ChenBH,FuTF. NeurobiolDis.2014;71:234-44.PMID:25131448 Knockingdown10-Formyltetrahydrofolatedehydrogenaseincreasedoxidativestressandimpededzebrafishembryogenesisbyobstructingmorphogeneticmovement. ChangWN,LeeGH,KaoTT,LinCY,HsiaoTH,TsaiJN,ChenBH,ChenYH,WuHR,TsaiHJ,FuTF. BiochimBiophysActa.2014Jul;1840(7):2340-50.PMID:28445049 Ethanol-inducedupregulationof10-formyltetrahydrofolatedehydrogenasehelpsrelieveethanol-inducedoxidativestress. HsiaoTH,LinCJ,ChungYS,LeeGH,KaoTT,ChangWN,ChenBH,HungJJ,FuTF. MolCellBiol.2014;34(3):498-509.PMID:  BPIQ,anovelsyntheticquinolinederivative,inhibitsgrowthandinducesmitochondrialapoptosisoflungcancercellsinvitroandinzebrafishxenograftmodel. ChiuCC,ChouHL,ChenBH,ChangKF,TsengCH,FongY,FuTF,ChangHW,WuCY,TsaiEM,LinSR,ChenYL. BMCCancer.2015;15:962.PMID:26672745 Concentrationeffectsofgrapeseedextractsinanti-oralcancercellsinvolvingdifferentialapoptosis,oxidativestress,andDNAdamage. YenCY,HouMF,YangZW,TangJY,LiKT,HuangHW,HuangYH,LeeSY,FuTF,HsiehCY,ChenBH*,ChangHW*.BMCComplementAlternMed.2015;15:94.PMID:25880412 AntiallergicPhorbolEsterfromtheSeedsofAquilariamalaccensis. KorinekM,WaghVD,LoIW,HsuYM,HsuHY,HwangTL,WuYC,ChengYB,ChenBH*,ChangFR*. IntJMolSci.2016;17(3).PMID:27007372 Inhibitoryeffectoftrans-ferulicacidonproliferationandmigrationofhumanlungcancercellsaccompaniedwithincreasedendogenousreactiveoxygenspeciesandβ-catenininstability. FongY,TangCC,HuHT,FangHY,ChenBH,WuCY,YuanSS,WangHD,ChenYC,TengYN,ChiuCC. ChinMed.2016Oct1;11:45. PMID:27733866 Anti-allergicpotentialofTyphoniumblumei:InhibitionofdegranulationviasuppressionofPI3K/PLCγ2phosphorylationandcalciuminflux. KorinekM,ChenKM,JiangYH,El-ShazlyM,StockerJ,ChouCK,HwangTL,WuYC,ChenBH*,ChangFR*. Phytomedicine.2016Dec15;23(14):1706-1715.doi:10.1016/j.phymed.2016.10.011. PMID:27912872 GrapeSeedExtractAttenuatesHepatitisCVirusReplicationandVirus-InducedInflammation. ChenWC,TsengCK,ChenBH,LinCK,LeeJC. FrontPharmacol.2016Dec21;7:490.doi:10.3389/fphar.2016.00490. PMID:28066241 Dualrolesofextracellularsignal-regulatedkinase(ERK)inquinolinecompoundBPIQ-inducedapoptosisandanti-migrationofhumannon-smallcelllungcancercells. FongY,WuCY,ChangKF,ChenBH,ChouWJ,TsengCH,ChenYC,WangHD,ChenYL,ChiuCC. CancerCellInt.2017Mar7;17:37.doi:10.1186/s12935-017-0403-0. PMID:28286419 TheTransgenicZebrafishDisplayFluorescenceReflectingtheExpressionalDynamicsofDihydrofolateReductase.ChangWN,ChiWY,KaoTT,TsaiJN,LiuW,LiangSS,ChiuCC,ChenBH*,FuTF*.Zebrafish2017doi:10.1089/zeb.2016.1381.PMID:28350247 InflammationModulatoryPhorbolEstersfromtheSeedof Aquilariamalaccensis.WaghVD,KorinekM,LoIW,HsuYM,ChenSL,HsuHY,HwangTL,WuYC,ChenBH*,ChengYB*,ChangFR*.J.Nat.Prod.2017doi:10.1021/acs.jnatprod.6b01096.[Epubaheadofprint]PMID:28445049 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Humannon‑smallcelllungcancercellscanbesensitizedtocamptothecinbymodulatingautophagy.ChiuYH,HsuSH,HsuHW,HuangKC,LiuW,WuCY,HuangWP,ChenJY,ChenBH,ChiuCC.IntJOncol.2018Nov;53(5):1967-1979.doi:10.3892/ijo.2018.4523.Epub2018Aug14.PMID:30106130 UsingambientmassspectrometryandLC-MS/MSfortherapiddetectionandidentificationofmultipleillicitstreetdrugs.ChiangCH,LeeHH,ChenBH,LinYC,ChaoYY,HuangYL.JFoodDrugAnal.2019Apr;27(2):439-450.doi:10.1016/j.jfda.2018.11.003.Epub2018Dec4.PMID:30987715 Studyoftheanti-allergicandanti-inflammatoryactivityofBrachychitonrupestrisandBrachychitondiscolorleaves(Malvaceae)usinginvitromodels.ThabetAA,YoussefFS,KorinekM,ChangFR,WuYC,ChenBH,El-ShazlyM,SingabANB,HwangTL.BMCComplementAlternMed.2018Nov9;18(1):299.doi:10.1186/s12906-018-2359-6.PMID:30413192 TherapeuticEffectofModulatingTREM-1viaAnti-inflammationandAutophagyinParkinson'sDisease.FengCW,ChenNF,SungCS,KuoHM,YangSN,ChenCL,HungHC,ChenBH,WenZH,ChenWF.FrontNeurosci.2019Aug2;13:769.doi:10.3389/fnins.2019.00769.eCollection2019.PMID:31440123 Supplementationwith5-formyltetrahydrofolatealleviatesultravioletB-inflictedoxidativedamageinfolate-deficientzebrafish.TuHC,LinMY,LinCY,HsiaoTH,WenZH,ChenBH,FuTF.EcotoxicolEnvironSaf.2019Oct30;182:109380.doi:10.1016/j.ecoenv.2019.109380.Epub2019Jul3.PMID:31279279 Athrombomodulin-likegeneiscrucialtothecollectivemigrationofepibolicblastomeresduringgermlayerformationandorganogenesisinzebrafish. LeeGH,ChangCL,ChiuWT,HsiaoTH,ChenPY,WangKC,KuoCH,ChenBH,ShiGY,WuHL,FuTF.JBiomedSci.2019Aug26;26(1):60.doi:10.1186/s12929-019-0549-2.PMID:31451113  Anovelzebrafishmodeltoemulatelunginjurybyfolatedeficiency-inducedswimbladderdefectivenessandprotease/antiproteaseexpressionimbalance.LeeGH,ChengNW,YuHH,TsaiJN,LiuT,WenZH,ChenBH,FuTF.SciRep.2019Sep2;9(1):12633.doi:10.1038/s41598-019-49152-7.PMID:31477754 Anti-InvasionandAntiangiogenicEffectsofStellettinBthroughInhibitionoftheAkt/GirdinSignalingPathwayandVEGFinGlioblastomaCells.ChengSY,ChenNF,LinPY,SuJH,ChenBH,KuoHM,SungCS,SungPJ,WenZH,ChenWF.Cancers(Basel).2019Feb14;11(2):220.doi:10.3390/cancers11020220.PMID:30769863  Astandardadditionmethodtoquantifyhistaminebyreductiveaminationandhydrophilicinteractionliquidchromatographycoupledwithtandemmassspectrometry.ShenPT,LinYR,ChenBH,HuangMF,ChengCW,ShiueYL,LiangSS.EurJMassSpectrom(Chichester).2019Oct;25(5):412-418.doi:10.1177/1469066719838966.Epub2019Apr20.PMID:31006258 Anti-inflammatory,hepatoprotectiveandantioxidantactivityofellagitanninisolatedfromMelaleucastyphelioides.Al-SayedE,KorinekM,EsmatA,ChenGY,ChengYB,HsiehPW,ChenBH,HwangTL.Phytochemistry.2020Sep;177:112429.doi:10.1016/j.phytochem.2020.112429.Epub2020Jun16.PMID:32559488 Increasedleptin-bexpressionandmetalloproteaseexpressioncontributedtothepyridoxine-associatedtoxicityinzebrafishlarvaedisplayingseizure-likebehavior.ChenPY,TsaiYW,ChangAY,ChangHH,HsiaoYH,HuangCW,SungPS,ChenBH,FuTF.BiochemPharmacol.2020Dec;182:114294.doi:10.1016/j.bcp.2020.114294.Epub2020Oct17.PMID:33080184 QualitativeandQuantitativeAnalysisofUkrainianIrisSpecies:AFreshLookonTheirAntioxidantContentandBiologicalActivities.MykhailenkoO,KorinekM,IvanauskasL,BezrukI,MyhalA,PetrikaitėV,El-ShazlyM,LinGH,LinCY,YenCH,ChenBH,GeorgiyantsV,HwangTL.Molecules.2020Oct8;25(19):4588.doi:10.3390/molecules25194588.PMID:33050063    研討會論文 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ChimericCD23thatdemonstratesIgEbindingcapacitycomparabletomembraneCD23.ChenBH,KellyAE,ConradDH.FASEBExperimentalBiology1999,Washington,DC,USA,1999. SearchingfortheCuretoAllergy:ConstructionandAnalysisofChimericCD23Trimers.ChenBH,ConradDH.The28thMid-AtlanticImmunobiologyConference,StateCollege,PA,USA,2000. StructuralandFunctionalAnalysisofMurineChimericCD23StalkDeletionMutantsinMediatingIgE-bindingActivity.ChenBH,ConradDH.FASEBExperimentalBiology2001,Orlando,FL,USA,2001. TemperatureeffectonIgEbindingtoCD23vsFcepsilonRI.MaC,ChenBH,KilmonMA,Chan-LiY,ConradDH.FASEBExperimentalBiology2002,NewOrleans,LO,USA,2002. SurfaceplasmonresonanceanalysisoftheCD23-IgEinteraction.RoushED,MaC,ChenBH,andConradDH.FASEBExperimentalBiology2002,NewOrleans,LO,USA,2002. TherapeuticapproachestargetingIgEandmIgE-expressingBcells.ChangTW,ChenHY,HuangJS,andChenBH.The17thWorldAllergyCongress,St.Petersburg,Russia,2003. Cloning,expression,purificationandcharacterizationofzebrafish10-formyltetrahydrofolatedehydrogenase.LinHC,ChangWN,ChenBHandFuTF.The22thJointAnnualConferenceofBiomedicalSciences,Taipei,Taiwan,2007. Cloningandcharacterizationofzebrafishserinehydroxymethyltransferases.ChangWN,TsaiJN,ChenBHandFuTF.The21thJointAnnualConferenceofBiomedicalSciences,Taipei,Taiwan,2007. StudiesontheAnti-folatePotentialofGrapeSeedExtract.KaoTT,WantKC,ChangTC,WuJJ,ChenBH,FuTF.The23thJointAnnualConferenceofBiomedicalSciences,Taipei,Taiwan,2008. 10-formyltetrahydrofolatedehydrogenaseisrequiredfornormaldevelopmentofcirculationsystemandneuronalmorphogenesisinzebrafishembryos.    FuTF,LinHC,LinCY,ChangWN,ChenBH.The11thAnnualMipTecConference,Basel,Switzerland,2009. TheinterplayofCD23andADAM10anditsroleinIgEsynthesis.MathewsJ,ChenBH,ConradDH.The96thAnnualMeetingofTheAmericanAssociationofImmunologists,Seattle,Washington,2009.     專利 COMPOSITIONSANDMETHODSOFANTIALLERGICPHORBOLESTERANDPHORBOLDERIVATIVESASTHEMAINACTIVEINGREDIENTSFROMTHESEEDSOFAQUILARIAMALACCENSIS.(發明者:Fang-rongChang,Bing-hungChen,Hsue-yinHsu,ChenHsieh,Hui-pingHsieh;發佈日期:2017/9/21;專利局:US;專利編號:20170266250) 文章瀏覽點擊數 818308 主選單 Menu 學系簡介 學系成員 學生專區 畢業生流向調查 師生榮譽 實習就業 科學工業園區人才培育補助計畫 招生訊息 新生專區 表單下載 聯絡我們 常用連結 Menu KMU首頁 KMU生命科學院 KMU臉書(官方版) KMU圖書資訊處 KMU電子資源查詢系統 KMU校務資訊系統 KMU公文整合系統 KMU數位學習系統 KMU課程互動系統(IRS) KMUWebGuide 教育部 科技部 2019© 高雄醫學大學生命科學院生物科技學系建議使用Chrome/Safari/Firefox瀏覽 地址：高雄市80708三民區十全一路100號高雄醫學大學生物科技學系 位置：第一教學大樓9,10樓(系辦公室:N943) 電話：07-3121101分機2709 傳真：07-3125339 信箱：[email protected]   Gototop