劉英明 - 中興大學生命科學系

專長領域 ：, 肌肉蛋白,生物物理,細胞分子生理,分子馬達. 電子信箱 ：, [email protected]. 實驗室網站：, https://orcid.org/0000-0002-8190-7629 ... 劉英明[教授] 肌肉生理生化研究室 辦公室電話： (04)22840416#717 實驗室電話： (04)22840416#718 傳  &nbsp   真 ： 實驗室位置： 生命科學大樓716室 最高學歷 ： 美國匹茲堡大學生理學博士 專長領域 ： 肌肉蛋白,生物物理,細胞分子生理,分子馬達  電子信箱 ： [email protected] 實驗室網站： https://orcid.org/0000-0002-8190-7629    學歷 經歷 研究方向 開設課程 研究室人員 學術著作   畢業學校 主修學門系所 學位 時期 美國匹茲堡大學 生理學 博士 1987/09-1992/04 國立台灣大學 動物學系 學士 1980/10-1984/06   服務機關 服務部門 職稱 時期 國立中興大學 生命科學系 教授 2005/08~迄今 國立中興大學 生命科學系 副教授 2002/08-2005/07 國立中興大學 動物學系 副教授 1994/08-2002/07 私立中山醫學大學 生理學系 副教授 1994/02-1994/07 美國哈佛大學 心血管研究部 博士後研究 1992/08-1994/01   研究興趣1臍帶幹細胞生長與分化2細胞骨骼以及肌肉細胞之分子馬達3建立研究心血管功能的實驗動物模式4造骨蛋白之生物功能研究主題1臍帶wharton'sjelly幹細胞生長與分化之分子調控2細胞骨骼以及肌肉分子馬達之細胞運動功能的研究3建立研究心血管功能的實驗動物模式4肌肉蛋白分子調控鈣離子活化肌肉收縮的分子機轉目前研究計畫1利用心肌傷害之實驗動物鼠來研究綠茶多酚保護心肌受損的機制探討(NSC98-2320-B-005-001-MY2)   博士班廖娟妙,陳建佑碩士班彭康維,許源彰,邱冠穎,許建生大學部研究助理博士後研究畢業生   A.期刊論文  1.SyHN,WuSL,WangWF,ChenCH,HuangYT,LiouYM,ChiouCS,PawlakCR,HoYJ.2010MPTP-induceddopaminergicdegenerationanddeficitsinobjectrecognitioninratsareaccompaniedbyneuroinflammationinthehippocampus.,PharmacolBiochemBehav.(SCI) 2.WangAL,*LiouY-M(co-firstauthor),PawlakCR,HoYJ2010InvolvementofNMDAreceptorsinbothMPTP-inducedneuroinflammationanddeficitsinepisodic-likememoryinWistarrats,BEHAVBRAINRES(2009,inpressdoi:10.1016/j.bbr.2009.11.006).(SCI) 3.ShiehDB,LiRY,LiaoJM,ChenGD,LiouYM*.2009EffectsofGenisteinonβ-cateninSignalingandSubcellularDistributionofActin-BindingProteinsinHumanUmbilicalCD105-PositiveStromalCells,(2009,Acceptedon12/2/09).(SCI) 4.WangWF,WuSL,LiouYM,WangAL,PawlakCR,HoYJ2009MPTPlesioncausesneuroinflammationanddeficitsinobjectrecognitioninWistarrats,BehavioralNeuroscience.123.pp.1261-1270.(SCI) 5.*LiouYM,HsiehSR,WuTJ.2009Greenteaandcardiachealth,CABReviews:PerspectivesinAgriculture,VeterinaryScience,NutritionandNaturalResources.4.no.020,pp.TCVGH-NCHU967602,TCVGH-NCH. 6.ShiehSR,TsaiDC,ChenJY,TsaiSW,*LiouYM2009Greenteaextractprotectsratsagainstmyocardialinfarctionassociatedwithleftanteriordescendingcoronaryarteryligation,ArticlesinPresS.PflugersArchiv-EuropeanJournalofPhysiology458.pp.631-342.(SCI) 7.LiouYM,WatanabeM,YumotoM,IshiwataS2009Regulatorymechanismofsmoothmusclecontractionstudiedwithgelsolin-treatedstripsofTaeniaCaeciinGuineaPig,AmJPhysiolCellPhysiol296.pp.C1024-C1033.(SCI) 8.ChangCP,LiuJC,LiouYM,ChangSS,ChenJY2008Theroleoffalselumensizeinpredictionofin-hospitalcomplicationsafteracutetypeBaorticdissection,JAmCollCardiol.52.pp.1170-1176.(SCI) 9.Tsai,SW,Wu,SK,Liou,YM,ShuSG2008EarlydevelopmentinWilliamsSyndrome.PediatricsInternational,PediatrInt.50.pp.221-224.(SCI) 10.*Liou,YM,KuoSC,HsiehSR2008Differentialeffectsofagreenteaderivedpolyphenol(-)-epigallocatechin-3-gallateontheacidosis-induceddecreaseintheCa2+sensitivityofcardiacandskeletalmuscle,PflugersArchiv-EJP,456.pp.787-800.(SCI) 11.Ying-MingLiou,H.Chao2007FluorescencespectroscopicanalysisoftheproximitychangesbetweenthecentralhelixoftroponinCBiochimicaetBiophysicaActa(BBA),Proteins&Proteomics1174.pp.466-473.(SCI) 12.Jiuan-MiawLiao,Pei-ChenHuang,Shwu-FenPan,Mei-JungChen,Kwong-ChungTung,Hsien-YuPeng,Chih-ChengShih,Ying-MingLiou,Gin-DenChen,andTzer-BinLin2007SpinalglutamatergicNMDA-dependentpelvicnerve-to-externalurethrasphincterreflexpotentiationcAmJPhysiol(RenalPhysiol)292,pp.F1791-1801.(SCI) 13.J.Liao,H.Ting,S.Lee,C.Yang,Y.Liou,M.Peng,S.Tsai,C.Lin,T.Li2006Electroacupuncture-inducedpressorandchronotropiceffectsinanesthetizedrats,AutonomicNeuroscience,124.pp.18-25.(SCI) 14.*LiouY.M.,L.Y.Chang,J.M.Liaw,M.J.Jiang.2005OsteopontinGeneExpressionintheAortaandtheHeartofPropylthiouracil-InducedHypothyroidMiceJournalofBiomedicalScience,vol.12,pp.869-880.(SCI) 15.*Liou,Y.M.andJCHChang2004DifferentialpHEffectonCalcium-InducedConformationalChangesofCardiacTroponinCComplexedwitJ,Biochem136(5).pp.683-692.(SCI) 16.Liou,Y.M.andM.W.Chen2003Calcium-DependentProtein-ProteinInteractionsInduceChangesinProximityRelationshipsofCys-48aEur,JBiochem.270.pp.2092-3100.(SCI) 17.*Liou,Y.M,YCTseng,JCCheng2002SpectrofluorometricAnalysisofLength-DependentConformationalChangesinCardiacTroponinC.J.MuscleRes,CellMolti.23.pp.309-315.(SCI) 18.Lung,F.T.,C.H.Chen,H.Y.Chen,C.C.Liou,andY.M.Liou2002Bindingpotencyofpeptidefragmentsoftype1collagencross-linkedN-TelopeptidemeasuredbyanEnProteinandPeptideLetters9(5),pp.451-457.(SCI) 19.*Liou,Y.-M,MJJiangandMCWu2002ChangesinThiolReactivityandExtractabilityofMyofibrilBoundCardiacTroponinCinPorcineMaliJ.Biochem,Tokyo32(2).pp.317-325.(SCI) 20.*Liou,Y.M.2001EffectsofSarcomerelengthandCa2+BindingonSHreactivityofmyofilamentboundtroponinCinporJpn,J.Physiol.51.pp.385-388.(SCI) 21.Liaw,R.-B.,H.C.Chang,Y.Y.Lai,C.T.Liu,I.C.Lu,Y.M.Liou,andM.C.Wu.2001PorcineStrssGeneofBerkshireBreedDetectedbyMS-PCRandDNASequencing,J.Chin.Anim.Sci.29. 22.*Liou,Y.-M,M.J.JiangandM.C.Wu.2000AlteredExpressionofCardiacMyosinIsozymesAssociatedwiththeMalignantHyperthermiaGenotypeinAnesthesiology93,pp.1312-1319.(SCI) B.研討會論文  1.*Tsai,DC,SRShieh,JYChen,SWTsai,#YMLiou.2008/03Astudyinvivowithcardio-protectionofgreenteaextractsonratmyocardialinfarctioninducedbycoronaryligation,The23rdJointAnnualConferenceofBiomedicalSciences.Taipei,Taiwan,March17-18,2008.. 2.*Li,RY,#YMLiou,THYing,Gin-DenChen,JMLiao,DBShieh2008Involvementofformin-2expressionintyrosinekinaserelatedcellgrowthofundifferentiatedculturedhumanumbilicalstemcells,The23rdJointAnnualConferenceofBiomedicalSciences.Taipei,Taiwan,March17-18,2008.. 3.#Liou,YM,Watanabe,M,Ishiwata,SI.2007Reconstitutionofcalcium-regulatedthinfilamentsintogelsolin-treatedskinnedsmoothmuscleofTaeniaCaeciinguineapigs,The22thJointAnnualConferenceofBiomedicalSciences.Taipei,Taiwan,March17-18,2007. 4.Liou,YM,*SCKuo2007Protectiveeffectsofgreenteapolyphenolsofcatechinandepigallocatechin-3-gallateonacidicpHreductionofCa2+sensitivityofcardiacmusclecontraction,The22ndJointAnnualConferenceofBiomedicalSciences.Taipei,Taiwan,March17-18,2007. 5.#Liou,YM,*JSChen2006Age-dependentdecreasesintheexpressionlevelsofmousebrainformin-2.,The21stJointAnnualConferenceofBiomedicalSciences.Taipei,Taiwan,March18-19,2006.. 6.W.Y.Chao,Y.M.Liou#.2005/03Studyoffluorescencespectroscopywithprotein-proteininteractionamongrecombinantchickenskeletaltroponinT,troponinCandtroponinIThe20thAnnualConferencesofBiomedicalScience.Taipei,Taiwan,Mar26-27,2005.. 7.Liou,YM,MWatanabe,andSIshiwata2005/02Studieswithreconstitutionofactinfilamentsintogelsolin-treatedskinnedsmoothmusclestripsof49thAmericanBiophysicalAnnualMeetingatLongBeach,CA,USA.,Feb12-16.. 8.*#Liou,YM,HLChao.2005EffectofcalciumandtroponinIontheproximityrelationshipbetweenthecentralhelixoftroponinCandtheC-terminalendoftroponinT,InternationalSymposiumCelebrating40thAnniversaryofTroponinDiscovery,the33rdNIPSConference.Okazaki,JAPAN,October25-28,2005. 9.Liou,YMandJCHChang.2004DifferentialeffectofpHoncalcium-inducedconformationalchangesofcardiactroponinCincomplex48thAmericanBiophysicalAnnualMeetingatBaltimore,MA,USA.,Feb23-27,2004.. 10.Liou,YMandMWChen2003Calcium-DependentProtein-ProteinInteractionsInduceChangesinProximityRelationshipsofCys-48a4thEasternAsianBiophysicalSymposium,Taipei,Taiwan,Nov.3-7,2003. 11.YPWen*,JCCheng,andYMLiou#2002SexeffectontroponinIdegradationinavianbloodserum,AnnualConferencesofBiomedicalScience.. 12.YCTseng*,JCCheng,YMLiou#2002PyreneexercimerfluorescenceassessingproximitychangesofCys-35andCys-84incardiactroponinCAnnualConferencesofBiomedicalScienc. 13.Liou,Y.M,YCTseng,JCCheng2002FluorescencespectroscopydiscerningsarcomerelengtheffectonconformationalchangesofCys-35and46thAmericanBiophysicalAnnualMeeting,atSanFrancisco,Ca,USA.,Feb23-27.. 14.Cheng,J.C.,etal.2001EffectsofgeneticbackgroundonmyosinisozymeexpressionandATPaseactivityofskeletalmuscleinAnnualConferrenceofBiomedicalScienc. 15.Goh,K.-S.,etal2001Age-dependentpolymorphicexpressionoftroponinTinthepectoralismajormuscleofdomesticchickeAnnualConferrenceofBiomedicalScienc. 16.Liou,YM,andMCWu2000EffectsofmechanicalinfluenceofvaryingsarcomerelengthonsulfhydrylreactivityofcardiactropBiophys.J.76:A257. 17.Goh,K.-S.,etal.2000PolymorphicexpressionofmyofilamentproteintroponinIinthepectoralismajormuscleofdomesticAnnualconferrenceofChineseAnimalScienc.