Benchmark Dose Tools | US EPA

The BMD is a range, rather than a fixed number. For example, the benchmark dose (lower confidence limit) (BMDL) can be regarded as a dose where the observable ... Skiptomaincontent Officialwebsitesuse.gov A.govwebsitebelongstoanofficialgovernmentorganizationintheUnitedStates. Secure.govwebsitesuseHTTPS Alock(LockAlockedpadlock)orhttps://meansyou’vesafelyconnectedtothe.govwebsite.Sharesensitiveinformationonlyonofficial,securewebsites. ContactUs BenchmarkDoseTools BMDS3.2Released PreviewversionsoftheBayesiancontinuousmodels--plususerinterfaceenhancements--highlightthisrelease.Downloadandlearnmoreabout thisupdate. CatReg3.1 InJune2017,EPA updatedtoa Windows-basedversionofCatReg forcategoricalregressionanalysis.Learnmoreby downloadingCatReg. 12 EPA'sBenchmarkDoseSoftware(BMDS)collectsandprovideseasyaccesstonumerousmathematicalmodelsthathelpriskassessorsestimatethequantitativerelationshipbetweenachemicaldoseandthetestsubject’sresponse. AspecificfocusofBMDSisestimatingastatisticalbenchmarkdose(BMD).TheBMDisachemicaldoseorconcentrationthatproducesapredeterminedchangeintheresponserateofanadverseeffect,suchasweightlossortumorincidence. TheBMDisarange,ratherthanafixednumber.Forexample,thebenchmarkdose(lowerconfidencelimit)(BMDL)canberegardedasadosewheretheobservablephysicaleffectislessthanthepredeterminedbenchmarkresponse(BMR). BMDmethodsareusedbytheU.S.EPAandthroughouttheworldfordose-responseanalysestosupportchemicalriskassessmentsandregulatoryactions.TheprimaryBMDtoolsdevelopedbytheU.S.EPAforthispurposearetheapplicationsBMDSandCategoricalRegression(CatReg). BMDSisconsistentwiththeEPARiskAssessmentForum's BenchmarkDoseTechnicalGuidanceDocument (U.S.EPA,2012)andthetechnicalguidancefor choosingtheappropriatestageofaMultistagemodelforcancermodeling. BMDSTrainingsat2021SRAVirtualConference Readaboutthetwohalf-dayBMDSandadvancedBMDanalysistrainings, scheduledforDecember5,atthe2021SRAVirtualConference. BMDS3 AboutBMDS:ApplicationHistory&PeerReviews AboutBMDS3 DownloadBMDS3 DownloadModelSourceCode Documentation FrequentQuestions ReleaseHistory BMDSSupport CatReg3 About CatReg 3 Download CatReg3 Documentation CatRegSupport RelatedLinks IntegratedRiskInformationSystem(IRIS) ConductingaHumanHealthRiskAssessment EPA'sRiskAssessment Process BasicInformationabout RiskAssessmentGuidelinesDevelopment EPARiskToolsandDatabases Training&Reference BMDS2.7 TrainingWebinars--methodsandmodels Report:ModelAveragingWorkshop(2015) BMDSGlossary Models&Tools Listof BenchmarkDoseModelsinBMDS BMDS2.7 (nolongersupported) BMDExpress  HealthAssessmentWorkspaceCollaborative(HAWC)  PROAST TechnicalGuidance BenchmarkDoseTechnicalGuidance(U.S.EPA,2012)ChoosingAppropriateStageofaMultistageModelforCancerModeling(BMDSTechnicalGuidance)(U.S.EPA,2014) ContactUstoaskaquestion,providefeedback,orreportaproblem.