subgroup analysis by right heart dysfunction (RHD)

Introduction: In the INSTAGE trial in subjects with IPF and severely impaired gas exchange, nintedanib plus sildenafil had a numerically greater effect on FVC ... Skiptomaincontent ChangesinbiomarkerswithnintedanibandsildenafilinsubjectswithIPFintheINSTAGEtrial:subgroupanalysisbyrightheartdysfunction(RHD) EricWhite,JürgenBehr,MartinKolb,TobyMMaher,CarinaIttrich,ClaudiaDiefenbach,KlausBRohr,ManuelQuaresma,BrunoCrestani EuropeanRespiratoryJournal202056:731;DOI:10.1183/13993003.congress-2020.731 EricWhite1UniversityofMichigan,DivisionofPulmonaryandCriticalCareMedicine,AnnArbor,Michigan,UnitedStatesofAmericaFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteForcorrespondence: [email protected]ürgenBehr2MedizinischeKlinikundPoliklinikV,UniversityofMunichandAsklepiosKlinikMünchen-Gauting,MemberoftheGermanCentreforLungResearch,Munich,GermanyFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteMartinKolb3McMasterUniversityandSt.Joseph’sHealthcare,Hamilton,Ontario,CanadaFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteTobyMMaher4NationalHeartandLungInstitute,ImperialCollegeLondon,UKandNationalInstituteforHealthResearchClinicalResearchFacility,RoyalBromptonHospital,London,UnitedKingdomFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteCarinaIttrich5BoehringerIngelheimPharmaGmbH&Co.KG,BiberachanderRiss,GermanyFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteClaudiaDiefenbach5BoehringerIngelheimPharmaGmbH&Co.KG,BiberachanderRiss,GermanyFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteKlausBRohr6BoehringerIngelheimInternationalGmbH,IngelheimamRhein,GermanyFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteManuelQuaresma6BoehringerIngelheimInternationalGmbH,IngelheimamRhein,GermanyFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissiteBrunoCrestani7HôpitalBichat,Pneumologie,Paris,FranceFindthisauthoronGoogleScholarFindthisauthoronPubMedSearchforthisauthoronthissite ArticleFigures&DataInfo&Metrics AbstractIntroduction:IntheINSTAGEtrialinsubjectswithIPFandseverelyimpairedgasexchange,nintedanibplussildenafilhadanumericallygreatereffectonFVCdeclinethannintedanibaloneinsubjectswithandwithoutechocardiographicsignsofRHDatbaseline.Aim:ToexaminebiomarkersrelevanttothepathophysiologyofIPFinsubgroupsbyRHDatbaselineintheINSTAGEtrial.Methods:SubjectswithIPFandDLco≤35%predictedwererandomisedtoreceivenintedanib150mgbidplussildenafil20mgtidornintedanib150mgbidplusplacebofor24weeks.Weanalysedfoldchangesinbiomarkersover24weeksinsubjectswith(n=117)andwithout(n=156)echocardiographicsignsofRHDatbaseline.Results:TreatmenteffectsweremostnotablydifferentbetweenRHDsubgroupsforICAM-1,KL-6andBGM.ReductionsinICAM-1withnintedanibplussildenafilvsnintedanibalonewereonlyobservedinsubjectswithRHD.ReductionsinKL-6withnintedanibplussildenafilvsnintedanibalonewereobservedinbothsubgroupsbutweremorepronouncedinsubjectswithRHD.ReductionsinBGMwithnintedanibplussildenafilvsnintedanibalonewereobservedover24weeksinsubjectswithoutRHD,butonlyuptoweek12inthosewithRHD.Conclusion:IntheINSTAGEtrial,theeffectsofnintedanibplussildenafilvsnintedanibaloneonbiomarkersvariedbythepresenceofRHDatbaseline.DownloadfigureOpeninnewtabDownloadpowerpointIdiopathicpulmonaryfibrosisBiomarkersTreatmentsFootnotesCitethisarticleas:EuropeanRespiratoryJournal2020;56:Suppl.64,731.Thisabstractwaspresentedatthe2020ERSInternationalCongress,insession“Respiratoryvirusesinthe"preCOVID-19"era”.ThisisanERSInternationalCongressabstract.Nofull-textversionisavailable.Furthermaterialtoaccompanythisabstractmaybeavailableatwww.ers-education.org(ERSmemberaccessonly).Copyright©theauthors2020 Previous Backtotop Vol56Issuesuppl64 TableofContents Email ThankyouforyourinterestinspreadingthewordonEuropeanRespiratorySociety.NOTE:Weonlyrequestyouremailaddresssothatthepersonyouarerecommendingthepagetoknowsthatyouwantedthemtoseeit,andthatitisnotjunkmail.Wedonotcaptureanyemailaddress. 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Alerts UserName* Password* SignIntoEmailAlertswithyourEmailAddress Email* CitationTools ChangesinbiomarkerswithnintedanibandsildenafilinsubjectswithIPFintheINSTAGEtrial:subgroupanalysisbyrightheartdysfunction(RHD) EricWhite,JürgenBehr,MartinKolb,TobyMMaher,CarinaIttrich,ClaudiaDiefenbach,KlausBRohr,ManuelQuaresma,BrunoCrestani EuropeanRespiratoryJournalSep2020,56(suppl64)731;DOI:10.1183/13993003.congress-2020.731 CitationManagerFormats BibTeXBookendsEasyBibEndNote(tagged)EndNote8(xml)MedlarsMendeleyPapersRefWorksTaggedRefManagerRISZotero Share ChangesinbiomarkerswithnintedanibandsildenafilinsubjectswithIPFintheINSTAGEtrial:subgroupanalysisbyrightheartdysfunction(RHD) EricWhite,JürgenBehr,MartinKolb,TobyMMaher,CarinaIttrich,ClaudiaDiefenbach,KlausBRohr,ManuelQuaresma,BrunoCrestani EuropeanRespiratoryJournalSep2020,56(suppl64)731;DOI:10.1183/13993003.congress-2020.731 ShareThisArticle: Copy JumpTo ArticleFigures&DataInfo&Metrics TweetWidgetFacebookLikeGooglePlusOne MoreinthisTOCSection BiomarkersofcollagenformationarepredictiveofIPFprogressionanddeath ChangesinbiomarkerswithnintedanibplussildenafilinsubjectswithIPFbypresenceofemphysemaintheINSTAGEtrial EffectsofnintedanibonmarkersofepithelialdamageinsubjectswithIPF:datafromtheINMARKtrial ShowmoreIdiopathicinterstitialpneumoniasRelatedArticles