Diethyltoluamide - AERU - University of Hertfordshire

Diethyltoluamide is an insect repellent. Little data is available regarding its environmental fate. It is moderately toxic to aquatic life. PPDB:PesticidePropertiesDataBase Top EnvironmentalFate Ecotoxicology HumanHealth Translations Home AtoZ:All AtoZ:Insecticides AtoZ:Herbicides AtoZ:Fungicides AtoZ:Otherproductconstituents Search Supportinformation Edithistory Purchasingandlicensing Diethyltoluamide Lastupdated:11/03/2022 (Alsoknownas:DEET;delphene;detamide) SUMMARY Diethyltoluamideisaninsectrepellent.Littledataisavailableregardingitsenvironmentalfate.Itismoderatelytoxictoaquaticlife.Diethyltoluamidehasamoderatemammalianoraltoxicity.Itisalsoaneurotoxinandanirritant. Dataalerts Thefollowingalertsarebasedonthedatainthetablesbelow.Anabsenceofanalertdoesnotimplythesubstancehasnoimplicationsforhumanhealth,biodiversityortheenvironmentbutjustthatwedonothavethedatatoformajudgement. Environmentalfate Ecotoxicity Humanhealth EnvironmentalfateModeratealert:Drainflow:ModeratelymobileWarning:Significantdataaremissing EcotoxicityModeratealert:Fishacuteecotoxicity:Moderate;Daphniaacuteecotoxicity:ModerateWarning:Significantdataaremissing HumanhealthHighalert:Neurotoxicant GENERALINFORMATION Description Aninsectrepellant,appliedtoskintoprotectagainstinsectbites Examplepestscontrolled Mosquitoes;Ticks;Fleas;Chiggers;Leeches;Gnats;Sandflies;Stableflies;Harvestmites Exampleapplications Humanskin;Clothing Efficacy&activity - Availabilitystatus - Introduction&keydates - UKregulatorystatus UKCOPRregulatorystatus Notapproved DateCOPRinclusionexpires Notapplicable UKLERAPstatus NoUKapprovalforuse ECRegulation1107/2009(repealing91/414) ECRegulation1107/2009status Notapproved Dossierrapporteur/co-rapporteur Notapplicable DateEC1107/2009inclusionexpires Notapplicable EUCandidateforsubstitution(CfS) Notapplicable ListedinEUdatabase No Approvedforuse(✓)underEC1107/2009inthefollowingEUMemberStates ATAustria BEBelgium BGBulgaria CYCyprus CZCzechRepublic DEGermany DKDenmark EEEstonia ELGreece &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp ESSpain FIFinland FRFrance HRCroatia HUHungary IEIreland ITItaly LTLithuania LULuxembourg &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp LVLatvia MTMalta NLNetherlands PLPoland PTPortugal RORomania SESweden SISlovenia SKSlovakia &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp Additionalinformation Alsousedin - Chemicalstructure Isomerism None Chemicalformula C₁₂H₁₇NO CanonicalSMILES CCN(CC)C(=O)C1=CC(=CC=C1)C IsomericSMILES - InternationalChemicalIdentifierkey(InChIKey) MMOXZBCLCQITDF-UHFFFAOYSA-N InternationalChemicalIdentifier(InChI) InChI=1S/C12H17NO/c1-4-13(5-2)12(14)11-8-6-7-10(3)9-11/h6-9H,4-5H2,1-3H3 2Dstructurediagram/imageavailable? Yes Generalstatus Pesticidetype Insecticide,Repellent Substancegroups Unclassifiedpesticide Minimumactivesubstancepurity 99% Knownrelevantimpurities - Substanceorigin Synthetic Modeofaction Worksbyblockinginsectreceptors CASRN 134-62-3 ECnumber 205-149-7 CIPACnumber Noneallocated USEPAchemicalcode 080301 PubChemCID 4284 Molecularmass 191.27 PIN(PreferredIdentificationName) N,N-diethyl-3-methylbenzamide IUPACname N,N-diethyl-m-toluamide CASname N,N-diethyl-3-methylbenzamide Otherstatusinformation - RelevantEnvironmentalWaterQualityStandards - HerbicideResistanceClassification(HRAC) Notapplicable HerbicideResistanceClassification(WSSA) Notapplicable InsecticideResistanceClassification(IRAC) Notknown FungicideResistanceClassification(FRAC) Notapplicable Examplesofrecordedresistance - Physicalstate Paleyellowtoamberliquidwitharomaticodour Formulations Property Value Examplemanufacturers&suppliersofproductsusingthisactivenoworhistorically - Exampleproductsusingthisactive - Formulationandapplicationdetails - ENVIRONMENTALFATE Property Value Source;qualityscore;andotherinformation Interpretation Solubility-Inwaterat20°C(mgl⁻¹) 912.0 V3V=ChemIDonlinedatabases/IPCSINCHEM(ChemID;IPCSINCHEM)3=Unverifieddataofknownsourceat25°C High Solubility-Inorganicsolventsat20°C(mgl⁻¹) - - - Meltingpoint(°C) -45.0 V3V=ChemIDonlinedatabases/IPCSINCHEM(ChemID;IPCSINCHEM)3=Unverifieddataofknownsource - Boilingpoint(°C) 292 E3E=Manufacturerssafetydatasheets3=Unverifieddataofknownsource - Degradationpoint(°C) - - - Flashpoint(°C) 155 E3E=Manufacturerssafetydatasheets3=Unverifieddataofknownsource - Octanol-waterpartitioncoefficientatpH7,20°C P 1.51X1002 Calculated - LogP 2.18 V3V=ChemIDonlinedatabases/IPCSINCHEM(ChemID;IPCSINCHEM)3=Unverifieddataofknownsource Low Fatsolubilityofresidues Solubility - - - Datatype - - - Density(gml⁻¹) 0.985 E3E=Manufacturerssafetydatasheets3=Unverifieddataofknownsource - DissociationconstantpKa)at25°C - - - - Vapourpressureat20°C(mPa) - - - Henry'slawconstantat25°C(Pam³mol⁻¹) - - - MaximumUV-visabsorptionLmol⁻¹cm⁻¹ - - - Surfacetension(mNm⁻¹) - - - Degradation Property Value Source;qualityscore;andotherinformation Interpretation Generalbiodegradability - Soildegradation(days)(aerobic) DT₅₀(typical) - - - DT₅₀(labat20°C) - - - DT₅₀(field) - - - DT₉₀(labat20°C) - - - DT₉₀(field) - - - DT₅₀modellingendpoint - - - Note - DissipationrateRL₅₀onplantmatrix Value - - - Note - DissipationrateRL₅₀onandinplantmatrix Value - - - Note - AqueousphotolysisDT₅₀(days)atpH7 Value - - - Note - AqueoushydrolysisDT₅₀(days)at20°CandpH7 Value - - - Note - Water-sedimentDT₅₀(days) - - - WaterphaseonlyDT₅₀(days) - - - Soiladsorptionandmobility Property Value Source;qualityscore;andotherinformation Interpretation Linear Kd - Q2Q=Miscellaneousinternetresources2=Unverifieddataofunknownsource Moderatelymobile Koc 277 Notesandrange Estimated Freundlich Kf - - - Kfoc - 1/n - Notesandrange - pHsensitivity - Fateindices Property Value Source;qualityscore;andotherinformation Interpretation GUSleachingpotentialindex - - - SCI-GROWgroundwaterindex(μgl⁻¹)fora1kgha⁻¹or1lha⁻¹applicationrate Value Cannotbecalculated - - Note - Potentialforparticleboundtransportindex - - - Potentialforlossviadrainflow - - - Bio-concentrationfactor BCF(lkg⁻¹) Lowrisk Q3Q=Miscellaneousinternetresources3=UnverifieddataofknownsourceBasedonLogP<3 Lowrisk CT₅₀(days) - - ECOTOXICOLOGY Terrestrialecotoxicology Property Value Source;qualityscore;andotherinformation Interpretation Mammals-AcuteoralLD₅₀(mgkg⁻¹) 1950 V3V=ChemIDonlinedatabases/IPCSINCHEM(ChemID;IPCSINCHEM)3=UnverifieddataofknownsourceRat Moderate Mammals-ShorttermdietaryNOEL (mgkg⁻¹) - - - (ppmdiet) - - Mammals-Chronic21dNOAEL(mgkg⁻¹bwd⁻¹) - - - Birds-AcuteLD₅₀(mgkg⁻¹) - - - Birds-Shorttermdietary(LC₅₀/LD₅₀) - - - Birds-Chronic21dNOEL(mgkg⁻¹bwd⁻¹) - - - Earthworms-Acute14dayLC₅₀(mgkg⁻¹) - - - Earthworms-ChronicNOEC,reproduction(mgkg⁻¹) - - - Soilmicro-organisms - - - Collembola AcuteLC₅₀(mgkg⁻¹) - - - ChronicNOEC(mgkg⁻¹) - - - Non-targetplants - - - - - - Honeybees(Apisspp.) ContactacuteLD₅₀(worstcasefrom24,48and72hourvalues-μgbee⁻¹) - - - OralacuteLD₅₀(worstcasefrom24,48and72hourvalues-μgbee⁻¹) - - - UnknownmodeacuteLD₅₀(worstcasefrom24,48and72hourvalues-μgbee⁻¹) - - - Chronic - - - Bumblebees(Bombusspp.) ContactacuteLD₅₀(worstcasefrom24,48and72hourvalues-μgbee⁻¹) - - - - OralacuteLD₅₀(worstcasefrom24,48and72hourvalues-μgbee⁻¹) - - - - Masonbees(Osmiaspp.) ContactacuteLD₅₀(worstcasefrom24,48and72hourvalues-μgbee⁻¹) - - - OralacuteLD₅₀(worstcasefrom24,48and72hourvalues-μgbee⁻¹) - - - Otherpollinators(1) AcuteLD₅₀(worstcasefrom24,48and72hourvalues-μginsect⁻¹) - - - Modeofexposure - Otherpollinators(2) AcuteLD₅₀(worstcasefrom24,48and72hourvalues-μginsect⁻¹) - - - Modeofexposure - Beneficialinsects(Ladybirds) - - - Beneficialinsects(Lacewings) - - - Beneficialinsects(Parasiticwasps) - - - Beneficialinsects(Predatorymites) - - - Beneficialinsects(Groundbeetles) - - - Aquaticecotoxicology Property Value Source;qualityscore;andotherinformation Interpretation Fish-Acute96hourLC₅₀(mgl⁻¹) 71.3 F3F=U.S.EPAECOTOXdatabase/U.S.EPApesticidefatedatabase/MiscellaneousWHOdocuments(USEPADatabasesRelatedtoPesticideRiskAssessment)3=UnverifieddataofknownsourceOncorhynchusmykiss Moderate Fish-Chronic21dayNOEC(mgl⁻¹) - - - Aquaticinvertebrates-Acute48hourEC₅₀(mgl⁻¹) 75.0 F3F=U.S.EPAECOTOXdatabase/U.S.EPApesticidefatedatabase/MiscellaneousWHOdocuments(USEPADatabasesRelatedtoPesticideRiskAssessment)3=UnverifieddataofknownsourceDaphniamagna Moderate Aquaticinvertebrates-Chronic21dayNOEC(mgl⁻¹) - - - Aquaticcrustaceans-Acute96hourLC₅₀(mgl⁻¹) - - - Sedimentdwellingorganisms-Acute96hourLC₅₀(mgl⁻¹) - - - Sedimentdwellingorganisms-Chronic28dayNOEC,static,water(mgl⁻¹) - - - Sedimentdwellingorganisms-Chronic28dayNOEC,sediment(mgkg⁻¹) - - - Aquaticplants-Acute7dayEC₅₀,biomass(mgl⁻¹) - - - Algae-Acute72hourEC₅₀,growth(mgl⁻¹) - - - Algae-Chronic96hourNOEC,growth(mgl⁻¹) - - - Mesocosmstudydata NOEAECmgl⁻¹ - - - NOEAECmgl⁻¹ - - - HUMANHEALTHANDPROTECTION General Property Value Source;qualityscore;andotherinformation Interpretation ThresholdofToxicologicalConcern(CramerClass) High(classIII) - - Mammals-AcuteoralLD₅₀(mgkg⁻¹) 1950 V3V=ChemIDonlinedatabases/IPCSINCHEM(ChemID;IPCSINCHEM)3=UnverifieddataofknownsourceRat Moderate Mammals-DermalLD₅₀(mgkg⁻¹bodyweight) 5000 V3V=ChemIDonlinedatabases/IPCSINCHEM(ChemID;IPCSINCHEM)3=UnverifieddataofknownsourceRat - Mammals-InhalationLC₅₀(mgl⁻¹) 5.95 V3V=ChemIDonlinedatabases/IPCSINCHEM(ChemID;IPCSINCHEM)3=UnverifieddataofknownsourceRat - OtherMammaltoxicityendpoints - - - ADI-AcceptableDailyIntake(mgkg⁻¹bwday⁻¹) - - - ARfD-AcuteReferenceDose(mgkg⁻¹bwday⁻¹) - - - AAOEL-AcuteAcceptableOperatorExposureLevel(mgkg⁻¹bwday⁻¹) - - - AOEL-AcceptableOperatorExposureLevel-Systemic(mgkg⁻¹bwday⁻¹) - - - Dermalpenetrationstudies(%) - - - DangerousSubstancesDirective76/464 - - - ExposureRoutes Public - Occupational - MRLs European EUMRLpesticidedatabase&nbsp GreatBritain GBMRLRegister&nbsp Notes - DrinkingWaterStandards - - - DrinkingWaterMAC(μgl⁻¹) - - - Mammaliandoseeliminationrouteandrate - - - Healthissues Specifichumanhealthissues Carcinogen Genotoxic Endocrinedisruptor Nodatafound A0A=Chromosomeaberration(EFSAdatabase)0=Nodata;B0B=DNAdamage/repair(EFSAdatabase)0=Nodata;C0C=Genemutation(EFSAdatabase)0=Nodata;D0D=Genomemutation(EFSAdatabase)0=Nodata;E0E=Unspecifiedgenotoxicitytype(miscellaneousdatasource)0=Nodata Nodatafound Reproduction/developmenteffects Acetylcholinesteraseinhibitor Neurotoxicant ?Possibly,statusnotidentified XNo,knownnottocauseaproblem ✓Yes,knowntocauseaproblem Respiratorytractirritant Skinirritant Skinsensitiser ✓Yes,knowntocauseaproblem ✓Yes,knowntocauseaproblem XNo,knownnottocauseaproblem Eyeirritant Phototoxicant &nbsp ✓Yes,knowntocauseaproblem Nodatafound &nbsp Generalhumanhealthissues Nofurtherinformationavailable Handlingissues Property Valueandinterpretation General Noinformationavailable CLPclassification2013 Health:H302,H315,H319Environment:H412 WHOClassification III(Slightlyhazardous) UNNumber - Wastedisposal&packaging - TRANSLATIONS Language Name English diethyltoluamide French - German - Danish - Italian - Spanish dietiltoluamida Greek - Polish dietylotoluamid Swedish - Hungarian - Dutch - Recordlastupdated: 11/03/2022 Contact: [email protected] Pleaseciteas: Lewis,K.A.,Tzilivakis,J.,Warner,D.andGreen,A.(2016)Aninternationaldatabaseforpesticideriskassessmentsandmanagement.HumanandEcologicalRiskAssessment:AnInternationalJournal,22(4),1050-1064.DOI:10.1080/10807039.2015.1133242 ALSOAVAILABLE: THEVSDB THEBPDB www.herts.ac.uk/aeru