Panax Notoginseng - Uses, Side Effects, and More - WebMD

Panax notoginseng is a plant. The leaves, fruit, and flowers are used to make medicine. However, the root is used the most commonly. MENUVITAMINS&SUPPLEMENTSCENTERFindaVitaminorSupplementFindaVitaminbyConditionAssessYourVitaminNeedsDRUGSANDMEDICATIONSCENTERFindaDrugMyMedicinePillIdentifierInteractionCheckerLatestDrugNewsFindaVitaminFindaPharmacyFIRSTAIDRESOURCESFirstAidA-ZFirstAidKit&WoundCareFirstAidMobileRELATEDTOVITAMINS&SUPPLEMENTSDrugs&MedicationsPillIdentifierMyMedicineInteractionCheckerDiet&WeightManagementFood&RecipesVitamins&SupplementspanaxnotoginsengPANAXNOTOGINSENG-Uses,SideEffects,andMoreOTHERNAME(S):Araliaquinquefoliavar.notoginseng,Chai-Jen-She...ShowMoreOTHERNAME(S):Araliaquinquefoliavar.notoginseng,Chai-Jen-She...ShowMoreOverviewUsesSideEffectsPrecautionsInteractionsDosingReviews(3)OverviewPanaxnotoginsengisaplant.Theleaves,fruit,andflowersareusedtomakemedicine.However,therootisusedthemostcommonly.BecarefulnottoconfusePanaxnotoginsengwithotherformsofginseng,suchasPanaxginsengorAmericanginseng.Panaxnotoginsengisusedtostoporslowdownbleeding.Itissometimestakenbypeoplewhohavenosebleeds,vomituporcoughupblood,orfindbloodintheirurineorfeces.Panaxnotoginsengisalsousedtorelievepain;andtoreduceswellingandbloodpressure.Itisalsousedforchestpain(angina),strokesandbleedinginthebrain,buildupoffatinthebloodvessels,heartattacks,andsomekindsofliverdisease.Itisalsousedtoimproveenergyandabilitytoexercise,toreducemusclesorenessfollowingexercise,andforosteoarthritisandrheumatoidarthritis.SomepeopleapplyPanaxnotoginsengdirectlytotheskintostopbleeding,helpwithbruisingorswelling,andtoimprovebloodmovementinthemuscles.Howdoesitwork?Panaxnotoginsengmightrelaxbloodvessels.Thiswouldimprovebloodflowandreducebloodpressure.SomeofthechemicalsinPanaxnotoginsengmightreduceswellingandprotecttheheart.Thereisn'tenoughinformationtoknowhowPanaxnotoginsengmightworkforotherconditions.Uses&Effectiveness?PossiblyEffectiveforChestpain(angina).ResearchshowsthatPanaxnotoginseng,takenbymouthorgivenasaninjection,seemstoreducesymptomsofchestpainwhenusedalongwithconventionalmedications.Itmightalsoreducehowoftenchestpainattacksoccurandhowlongtheattackslastwhentheydooccur.TheseproductsaregivenbyadoctorincountrieslikeChina.Bleedingwithintheskull(intracranialhemorrhage).ResearchshowsthatPanaxnotoginsenginjectionsmightimproverecoveryandreducetheriskofdeathinpeoplethathavehadbleedinginthebrain,usuallybecauseofastroke.TheseproductsaregivenbyadoctorincountrieslikeChina.Stroke.ResearchshowsthatgivingPanaxnotoginsenginjectionsmightincreasethechanceofapersonimprovingorrecoveringafterastroke.TheseproductsaregivenbyadoctorincountrieslikeChina.PossiblyIneffectiveforHeartattack.Panaxnotoginsengdoesnotseemtopreventheartattacksinpeoplewithheartdiseasewhenusedalongwithconventionaltherapy.InsufficientEvidenceforAthleticperformance.EarlyresearchshowsthattakingPanaxnotoginsengfor30daysmighthelpnon-athletesexerciseforlonger.Musclesorenesscausedbyexercise.TakingPanaxnotoginsengmightreducemusclesorenessafewdaysafteradownhillrun.Buttheimprovementissmall.Osteoarthritis.SomeresearchshowsthattakingacombinationofPanaxnotoginseng,Siberianginseng,andrehmanniadailymighthelppatientswithosteoarthritismovebetter.However,itdoesnotseemtohelpreducepainorstiffness.Bleeding.Highbloodpressure.Improvingbloodflow.Liverdisease.Pain.Swelling.Otherconditions.MoreevidenceisneededtoratetheeffectivenessofPanaxnotoginsengfortheseuses.SideEffectsWhentakenbymouth:PanaxnotoginsengisPOSSIBLYSAFEwhentakenbymouth.Itcancausesomesideeffectssuchasdrymouth,flushedskin,rash,nervousness,sleepproblems,headache,nausea,andvomiting.WhengivenbyIVorasashot:PanaxnotoginsengisPOSSIBLYSAFEwhengivenwithaneedlebyaphysician.Itcancausesomesideeffectssuchasrash,nervousness,headache,nausea,andvomiting.SpecialPrecautionsandWarningsWhentakenbymouth:PanaxnotoginsengisPOSSIBLYSAFEwhentakenbymouth.Itcancausesomesideeffectssuchasdrymouth,flushedskin,rash,nervousness,sleepproblems,headache,nausea,andvomiting.WhengivenbyIVorasashot:PanaxnotoginsengisPOSSIBLYSAFEwhengivenwithaneedlebyaphysician.Itcancausesomesideeffectssuchasrash,nervousness,headache,nausea,andvomiting.Pregnancyandbreast-feeding:Don'ttakePanaxnotoginsengifyouarepregnantorbreast-feeding.ItisLIKELYUNSAFE.OneofthechemicalsinPanaxnotoginsenghascausedbirthdefectsinanimals.Hormone-sensitiveconditionssuchasbreastcancer,uterinecancer,ovariancancer,endometriosis,oruterinefibroids:Panaxnotoginsengmightactlikeestrogen.Ifyouhaveanyconditionthatmightbemadeworsebyexposuretoestrogen,don'tusePanaxnotoginseng.Interactions?ModerateInteractionBecautiouswiththiscombinationAspirininteractswithPANAXNOTOGINSENGPanaxnotoginsengalongwithaspirinmightincreasehowmuchaspirinandPanaxnotoginsengisintheblood.Althoughthishasnotbeenshowninhumans,takingPanaxnotoginsengwithaspirinmightincreasesideeffectsofbothaspirinandPanaxnotoginseng.CaffeineinteractswithPANAXNOTOGINSENGCaffeineischangedandbrokendownbytheliver.Panaxnotoginsengmightincreasehowquicklytheliverbreaksdowncaffeine.TakingPanaxnotoginsengalongwithcaffeinemightdecreasetheeffectsofcaffeine.Medicationschangedbytheliver(CytochromeP4501A2(CYP1A2)substrates)interactswithPANAXNOTOGINSENGSomemedicationsarechangedandbrokendownbytheliver.Panaxnotoginsengmightincreasehowquicklytheliverbreaksdownsomemedications.TakingPanaxnotoginsengalongwithsomemedicationsthatarechangedbythelivermightdecreasetheeffectivenessofthesemedications.BeforetakingPanaxnotoginseng,talktoyourhealthcareproviderifyoutakeanymedicationsthatarechangedbytheliver. Someofthesemedicationsthatarechangedbytheliverincludeclozapine(Clozaril),cyclobenzaprine(Flexeril),fluvoxamine(Luvox),haloperidol(Haldol),imipramine(Tofranil),mexiletine(Mexitil),olanzapine(Zyprexa),pentazocine(Talwin),propranolol(Inderal),tacrine(Cognex),zileuton(Zyflo),zolmitriptan(Zomig),andothers.DosingThefollowingdoseshavebeenstudiedinscientificresearch:ADULTSBYMOUTH:Forchestpain(angina):200-400mgofPanaxnotoginsengextracthasbeentaken2-3timesdailyfor4-6weeks.Also,1gramofPanaxnotoginsengpowderhasbeentaken3timesdaily.Forstroke:AspecificextractofPanaxnotoginsengroot(sanchitongtshu)hasbeentakenthreetimesdailyfor28days.WITHANEEDLE:Forchestpain(angina):400-500mgofPanaxnotoginsengextracthasbeeninjectedintotheveinorgivenasashotdailyfor2-4weeks.Forbleedingwithintheskull(intracranialhemorrhage):140-800mgofPanaxnotoginsengextracthasbeeninjectedintotheveindaily,usuallyfor2-4weeks.Forstroke:Injectionscontaining200-600mgofPanaxnotoginsenghavebeengivendailyfor2-4weeks.NextViewReferencesREFERENCES:Park,S.H.,Kim,S.K.,Shin,I.H.,Kim,H.G.,andChoe,J.Y.EffectsofAIFonKneeOsteoarthritisPatients:Double-blind,RandomizedPlacebo-controlledStudy.KoreanJPhysiolPharmacol.2009;13(1):33-37.Viewabstract.BenskyD,GambleA,KaptchukT.ChineseHerbalMedicineMateriaMedica.Seattle,WA:EastlandPress,1996:359-60.ChanLY,ChiuPY,LauTK.Anin-vitrostudyofginsenosideRb(1)-inducedteratogenicityusingawholeratembryoculturemodel.HumReprod2003;18:2166-8..Viewabstract.ChanP,TomlinsonB.AntioxidanteffectsofChinesetraditionalmedicine:focusontrilinoleinisolatedfromtheChineseherbsanchi.JClinPharmacol2000;40:457-61.Viewabstract.ChanRY,ChenWF,DongA,etal.Estrogen-likeactivityofginsenosideRg1derivedfromPanaxnotoginseng.JClinEndocrinolMetab2002;87:3691-5.Viewabstract.ChenMY,ShaoL,ZhangW,etal.MetabolicanalysisofPanaxnotoginsengsaponinswithgutmicrobiota-mediatedbiotransformationbyHPLC-DAD-Q-TOF-MS/MS.JPharmBiomedAnal.2018;150:199-207.Viewabstract.CiceroAF,VitaleG,SavinoG,ArlettiR.Panaxnotoginseng(Burk.)effectsonfibrinogenandlipidplasmalevelinratsfedonahigh-fatdiet.PhytotherRes2003;17:174-8.Viewabstract.DuXF,YinXP,ZhangGL,ShiHJ,ShaoMH.InterstitialgranulomatousdrugreactiontoaChineseherbextract.EurJDermatol.2012May-Jun;22(3):419-20.Viewabstract.FaulksRM,SouthonS.Challengestounderstandingandmeasuringcarotenoidbioavailability.BiochimBiophysActa2005;1740:95-100.Viewabstract.HeL,ChenX,ZhouM,etal.Radix/rhizomanotoginsengextract(sanchitongtshu)forischemicstroke:arandomizedcontrolledstudy.Phytomedicine2011;18:437-42.Viewabstract.HuangKC.ThePharmacologyofChineseHerbs.2nded.NewYork,NY:CRCPress,LLC1999:101-102.HudaultS,LievinV,Bernet-CamardMF,ServinAL.AntagonisticactivityexertedinvitroandinvivobyLactobacilluscasei(strainGG)againstSalmonellatyphimuriumC5infection.ApplEnvironMicrobiol1997;63:513-8.Viewabstract.LamSK,NgTB.Axylanasefromrootsofsanchiginseng(Panaxnotoginseng)withinhibitoryeffectsonhumanimmunodeficiencyvirus-1reversetranscriptase.LifeSci2002;70:3049-58.Viewabstract.LamSK,NgTB.Pananotin,apotentantifungalproteinfromrootsofthetraditionalChinesemedicinalherbPanxnotoginseng.PlantaMed2002;68:1024-8.Viewabstract.LiC,XuT,ZhouP,etal.Post-marketingsafetysurveillanceandre-evaluationofXueshuantonginjection.BMCComplementAlternMed.2018;18(1):277.Viewabstract.LiangMT,LauWY,SokmenB,SpaldingTW,ChuangWJ.EffectsofPanaxnotoginseng(Chineseginseng)andacuteexerciseonpostprandialglycemiainnon-diabeticadults.JComplementIntegrMed.2012Jan4;8.pii:/j/jcim.2011.8.issue-1/1553-3840.1402/1553-3840.1402.xml.Viewabstract.LiangMT,PodolkaTD,ChuangWJ.Panaxnotoginsengsupplementationenhancesphysicalperformanceduringenduranceexercise.JStrengthCondRes.2005Feb;19(1):108-14.Viewabstract.LiuR,QinM,HangP,LiuY,ZhangZ,LiuG.EffectsofPanaxnotoginsengsaponinsontheactivitiesofCYP1A2,CYP2C9,CYP2D6andCYP3A4inratsinvivo.PhytotherRes.2012Aug;26(8):1113-8.Viewabstract.PumpaKL,FallonKE,BensoussanA,PapaliaS.TheeffectsofPanaxnotoginsengondelayedonsetmusclesorenessandmuscledamageinwell-trainedmales:adoubleblindrandomisedcontrolledtrial.ComplementTherMed.2013Jun;21(3):131-40.Viewabstract.SenguptaS,TohSA,SellersLA,etal.Modulatingangiogenesis:theyinandtheyanginginseng.Circulation2004;110:1219-25.Viewabstract.ShangQ,XuH,LiuZ,ChenK,LiuJ.OralPanaxnotoginsengPreparationforCoronaryHeartDisease:ASystematicReviewofRandomizedControlledTrials.EvidBasedComplementAlternatMed.2013;2013:940125.Viewabstract.ShenQ,LiJ,ZhangC,WangP,MohammedA,NiS,TangZ.Panaxnotoginsengsaponinsreducehigh-riskfactorsforthrombosisthroughperoxisomeproliferator-activatedreceptor-ypathway.BiomedPharmacother.2017Dec;96:1163-69.Viewabstract.SievenpiperJL,ArnasonJT,LeiterLA,VuksanV.Decreasing,nullandincreasingeffectsofeightpopulartypesofginsengonacutepostprandialglycemicindicesinhealthyhumans:theroleofginsenosides.JAmCollNutr2004;23:248-58.Viewabstract.SongH,WangP,LiuJ,WangC.PanaxnotoginsengPreparationsforUnstableAnginaPectoris:ASystematicReviewandMeta-Analysis.PhytotherRes.2017Jun20.Viewabstract.TianZ,PangH,DuS,LuY,ZhangL,WuH,GuoS,WangM,ZhangQ.EffectofPanaxnotoginsengsaponinsonth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