[PDF] Revisiting the hallmarks of cancer. | Semantic Scholar

This work defines seven hallmarks of cancer: selective growth and proliferative advantage, altered stress response favoring overall survival, ... SkiptosearchformSkiptomaincontentSkiptoaccountmenuYouarecurrentlyoffline.Somefeaturesofthesitemaynotworkcorrectly.CorpusID:5582239Revisitingthehallmarksofcancer.@article{Fouad2017RevisitingTH, title={Revisitingthehallmarksofcancer.}, author={Y.FouadandCarmenMarianaAanei}, journal={Americanjournalofcancerresearch}, year={2017}, volume={75}, pages={ 1016-1036 } }Y.Fouad,C.AaneiPublished2017BiologyAmericanjournalofcancerresearchThehallmarksofcancerdescribedbyHanahanandWeinberghaveprovedseminalinourunderstandingofcancer'scommontraitsandinrationaldrugdesign.Notfreeofcritiqueandwithunderstandingofdifferentaspectsoftumorigenesiscomingintoclearerfocusintherecentyears,weattempttodrawamoreorganizedandupdatedpictureofthecancerhallmarks.Wedefinesevenhallmarksofcancer:selectivegrowthandproliferativeadvantage,alteredstressresponsefavoringoverallsurvival… ExpandViewonPubMedajcr.usSavetoLibrarySaveCreateAlertAlertCiteShareThisPaper503CitationsHighlyInfluentialCitations11BackgroundCitations206MethodsCitations2ViewAllFiguresfromthispaperfigure1figure2figure3503CitationsCitationTypeCitationTypeAllTypesBackgroundCitationsMethodsCitationsHasPDFPublicationTypeAuthorMoreFiltersMoreFiltersFiltersSortbyRelevanceSortbyMostInfluencedPapersSortbyCitationCountSortbyRecencyInvasionandmetastasis:theelusivehallmarkofcancerT.Meirson,H.Gil-Henn,A.SamsonBiologyOncogene2019TLDRItisarguedthattheimportanceoftheinvasionandmetastasishallmarkderivesfromthemostdefiningfeatureofmalignancy,whichentailstheabilitytoinvade,tospread,andtocolonizedistanttissues.Expand21View2excerpts,citesbackgroundSaveAlertAllcancerhallmarksleadtodiversityA.Alkhazraji,M.Elgamal,ShiHuiAng,V.ShivarovBiology,Chemistry2019TLDRThisworkhasproposedanextensionofthecancerhallmarksconceptbasedontherecentrefinementsoftheunderstatingofevolutionarymechanismsunderlyingcancerinitiationandprogressionusinghigh-throughputomicstechnologies.Expand3PDFView1excerpt,citesbackgroundSaveAlertComputationalmethodsintumorimmunology.B.Bhinder,O.ElementoBiologyMethodsinenzymology20201SaveAlertMolecularprinciplesofmetastasis:ahallmarkofcancerrevisitedJawadFares,M.Fares,HusseinH.Khachfe,HamzaA.Salhab,Y.FaresBiologySignalTransductionandTargetedTherapy2020TLDRTheauthorsexploretherecentadvancementsinthefieldofmetastasisandhighlightthelatestinsightsthatcontributetoshapingthishallmarkofcancer.Expand163HighlyInfluencedPDFView4excerpts,citesbackgroundSaveAlertHallmarksofCancers:PrimaryAntibodyDeficiencyVersusOtherInbornErrorsofImmunityH.Abolhassani,YatingWang,L.Hammarström,Q.Pan-HammarströmBiology,MedicineFrontiersinImmunology2021TLDRComparedtheoncologichallmarksandthemoleculardefectsunderlyingPADwithotherIEIentitiesarecomparedtodissecttheimpactofavoidingimmunedestruction,genomeinstability,andmutation,enablingreplicativeimmortality,tumor-promotinginflammation,resistingcelldeath,sustainingproliferativesignaling,evadinggrowthsuppressors,deregulatingcellularenergetics,inducingangiogenesis,andactivatinginvasionandmetastasisinthesegroupsofpatients.Expand1PDFSaveAlertUnderstandingtheHallmarkCharacteristicsofCancerC.ComptonBiology2020TLDRThischapterdiscusseshowmutationofgenesindevelopingcancersleadstochangesincellbehaviorsthatarecharacteristicofmalignantneoplasmsandallowsthemtooutcompeteandovertakenormalcells.ExpandSaveAlertCancerStemCells:NewHorizonsinCancerTherapiesS.Pathak,A.BanerjeeBiology2020TLDRAnattempthasbeenmadetoprovideanoverallideaondifferentaspectsofcancerstemcells,optimizationofrateandtypeofcellgrowth,andtheirassociativecurestrategybyadoptingawell-definedscientificperspective.Expand1View3excerpts,citesbackgroundSaveAlertCancer,Mankind′sChallengeYingyuCuiMedicine,BiologyCurrentCancerReports2019Cancer,ormalignanttumour,isagroupofdiseasesdefinedbytheuncontrollablegrowthofthetransformedcells,andtheircapabilitiesofinvasionintosurroundinghealthytissuesandmetastasis…Expand4PDFView1excerpt,citesbackgroundSaveAlertTheHallmarksofGlioblastoma:Heterogeneity,IntercellularCrosstalkandMolecularSignatureofInvasivenessandProgressionF.Torrisi,CristianaAlberghina,+13authorsR.ParentiBiologyBiomedicines2022TLDRTheevidencepresentedprovidesthepromisingviewthatglioblastomarepresentsinterconnectedhallmarksthatmayledtoabetterunderstandingoftumorpathophysiology,thereforedrivingthedevelopmentofnewtherapeuticstrategiesandapproaches.Expand1HighlyInfluencedPDFView4excerpts,citesbackgroundandmethodsSaveAlertEvolutionandeffectivenessofoncolyticvirotherapyasacancertreatmentD.Perera,S.DiasMedicine,Biology2019TLDROncolyticvirotherapyusesvirusesthatselectivelyreplicateandlysecancercells,whichtendstoshowsuperiorityovertheconventionalmethodsintreatingcancers.ExpandSaveAlert...12345...ReferencesSHOWING1-10OF211REFERENCESSORTBYRelevanceMostInfluencedPapersRecency2011:theimmunehallmarksofcancerF.Cavallo,C.DeGiovanni,P.Nanni,G.Forni,P.LolliniBiology,MedicineCancerImmunology,Immunotherapy2010TLDRGeneticandmoleculardefinitionofthesethreeimmunehallmarksofcancerofferstheopportunitytolearnhowtodeployspecificcountermeasurestoreversethesituationinfavoroftheimmunesystemand,eventually,thepatient.Expand323PDFView2excerpts,referencesbackgroundSaveAlertThecurrentstateofcancermetabolismR.Cairns,T.MakBiologyNatureReviewsCancer2016TLDRFindingsduringthepasttwodecadeshaveonceagainhighlightedthatchangestometabolicprocessesarerequiredforcellstoescapefromtheirdefinedrolesasintegratedpartsofatissueandorgansystem,andbecomeanindependentcloneofcellsthatmanifestsitselfasmalignantdisease.Expand52View1excerpt,referencesbackgroundSaveAlertDistinctivepropertiesofmetastasis-initiatingcells.T.Celià-Terrassa,YibinKangBiology,MedicineGenes&development2016TLDRBetterunderstandingofthemolecularandcellularhallmarksofMICswillfacilitatethedevelopmentanddeploymentofnoveltherapeuticstrategies.Expand224PDFView1excerpt,referencesbackgroundSaveAlertConflictingrolesofmoleculesinhepatocarcinogenesis:paradigmorparadox.G.FengBiology,MedicineCancercell201298PDFView2excerpts,referencesbackgroundSaveAlertRegulationofcancercellmetabolismR.Cairns,I.Harris,T.MakBiology,MedicineNatureReviewsCancer2011TLDRInterestinthetopicoftumourmetabolismhaswaxedandwanedoverthepastcentury,butithasbecomeclearthatmanyofthesignallingpathwaysthatareaffectedbygeneticmutationsandthetumourmicroenvironmenthaveaprofoundeffectoncoremetabolism,makingthistopiconceagainoneofthemostintenseareasofresearchincancerbiology.Expand3,856PDFView2excerpts,referencesbackgroundSaveAlertCancerassociatedfibroblastsincancerpathogenesis.O.Franco,AubieK.Shaw,D.Strand,S.HaywardMedicine,BiologySeminarsincell&developmentalbiology2010328PDFView2excerpts,referencesbackgroundSaveAlertTheagingofthe2000and2011HallmarksofCancerreviews:AcritiqueC.Sonnenschein,A.SotoBiologyJournalofBiosciences2013TLDRThisworkcritiquesthevalueofeightbroadfeaturesofcancerphenotypesbasedonthenumerousintrinsicinconsistenciesinthedataandintherationalebehindSMT,andproposesanalternativeinterpretationofthesamedataplusdatamostlyignoredbyHanahanandWeinberg,basedonevolutionarilyrelevantpremises.Expand101PDFView3excerpts,referencesbackgroundSaveAlertGeneticdeterminantsofcancermetastasisD.Nguyen,J.MassaguéMedicine,BiologyNatureReviewsGenetics2007TLDRWithknowledgecementedindecadesofresearchintotumour-initiatingevents,currentexperimentalandconceptualmodelsarebeginningtoaddressthegeneticbasisforcancercolonizationofdistantorgans.Expand761PDFView1excerpt,referencesbackgroundSaveAlertAccessoriestothecrime:functionsofcellsrecruitedtothetumormicroenvironment.D.Hanahan,L.CoussensBiologyCancercell20123,012PDFView3excerpts,referencesbackgroundSaveAlertTumorigenesis:ittakesavillageD.P.Tabassum,K.PolyakMedicineNatureReviewsCancer2015TLDRThisReviewhighlightsstudiesthatdemonstrateinteractionsamongsubpopulationswithintumoursthataddagreaterlayerofcomplexitytotherapeuticinterventionsinheterogeneoustumours,oftenleadingtoapoorprognosis.Expand410View1excerpt,referencesbackgroundSaveAlert...12345...RelatedPapersAbstractFigures503Citations211ReferencesRelatedPapersByclickingacceptorcontinuingtousethesite,youagreetothetermsoutlinedinourPrivacyPolicy,TermsofService,andDatasetLicenseACCEPT&CONTINUE