Opticin - Wikipedia

Opticin is a protein that in humans is encoded by the OPTC gene. OPTC. Identifiers. Aliases · OPTC, OPT, opticin. External IDs, OMIM: 605127 MGI: 2151113 ... Opticin FromWikipedia,thefreeencyclopedia Jumptonavigation Jumptosearch Protein-codinggeneinthespeciesHomosapiens OPTCIdentifiersAliasesOPTC,OPT,opticinExternalIDsOMIM:605127MGI:2151113HomoloGene:8652GeneCards:OPTCGenelocation(Human)Chr.Chromosome1(human)[1]Band1q32.1Start203,494,153bp[1]End203,508,949bp[1]Genelocation(Mouse)Chr.Chromosome1(mouse)[2]Band1E4|158.02cMStart133,824,937bp[2]End133,835,737bp[2]RNAexpressionpatternBgeeTopexpressedin tibialisanteriormuscle deltoidmuscle smoothmuscletissue placenta myometrium leftuterinetube urinarybladder sensoryorgan face gastricmucosaMorereferenceexpressiondataBioGPSMorereferenceexpressiondataGeneontologyMolecularfunction extracellularmatrixstructuralconstituent Cellularcomponent extracellularregion GO:0005578extracellularmatrix Biologicalprocess extracellularmatrixdisassembly Sources:Amigo/QuickGOOrthologsSpeciesHumanMouseEntrez26254269120EnsemblENSG00000188770ENSMUSG00000010311UniProtQ9UBM4Q920A0RefSeq(mRNA)NM_014359NM_001160420NM_001160421NM_001160422NM_054076NM_001395557NM_001395558RefSeq(protein)NP_055174NP_001153892NP_001153893NP_001153894NP_473417NP_001382486NP_001382487Location(UCSC)Chr1:203.49–203.51MbChr1:133.82–133.84MbPubMedsearch[3][4]WikidataView/EditHumanView/EditMouse OpticinisaproteinthatinhumansisencodedbytheOPTCgene.[5][6] OpticinbelongstoclassIIIofthesmallleucine-richrepeatprotein(SLRP)family.Membersofthisfamilyaretypicallyassociatedwiththeextracellularmatrix.Opticinispresentinsignificantquantitiesinthevitreousoftheeyeandalsolocalizestothecornea,iris,ciliarybody,opticnerve,choroid,retina,andfetalliver.Opticinmaynoncovalentlybindcollagenfibrilsandregulatefibrilmorphology,spacing,andorganization.Theopticingeneismappedtoaregionofchromosome1thatisassociatedwiththeinheritedeyediseasesage-relatedmaculardegeneration(AMD)andposteriorcolumnataxiawithretinosapigmentosa(AXPC1).[6] References[edit] ^abcGRCh38:Ensemblrelease89:ENSG00000188770-Ensembl,May2017 ^abcGRCm38:Ensemblrelease89:ENSMUSG00000010311-Ensembl,May2017 ^"HumanPubMedReference:".NationalCenterforBiotechnologyInformation,U.S.NationalLibraryofMedicine. ^"MousePubMedReference:".NationalCenterforBiotechnologyInformation,U.S.NationalLibraryofMedicine. ^ReardonAJ,LeGoffM,BriggsMD,McLeodD,SheehanJK,ThorntonDJ,BishopPN(Feb2000)."Identificationinvitreousandmolecularcloningofopticin,anovelmemberofthefamilyofleucine-richrepeatproteinsoftheextracellularmatrix".JBiolChem.275(3):2123–9.doi:10.1074/jbc.275.3.2123.PMID 10636917. ^ab"EntrezGene:OPTCopticin". Furtherreading[edit] HobbyP,WyattMK,GanW,et al.(2000)."Cloning,modeling,andchromosomallocalizationforasmallleucine-richrepeatproteoglycan(SLRP)familymemberexpressedinhumaneye".Mol.Vis.6:72–8.PMID 10837509. FriedmanJS,DucharmeR,RaymondV,WalterMA(2000)."Isolationofanoveliris-specificandleucine-richrepeatprotein(oculoglycan)usingdifferentialselection".Invest.Ophthalmol.Vis.Sci.41(8):2059–66.PMID 10892843. ArmerdingD,FuhlbriggeRC,KiefferJD,KupperTS(2001)."TonsillarBcellsdonotexpressPSGL-1,butasignificantfractiondisplaysthecutaneouslymphocyteantigenandexhibitseffectiveE-andP-selectinligandactivity".Int.Arch.AllergyImmunol.126(1):78–90.doi:10.1159/000049497.PMID 11641609.S2CID 45610233. FriedmanJS,FaucherM,HiscottP,et al.(2002)."Proteinlocalizationinthehumaneyeandgeneticscreenofopticin".Hum.Mol.Genet.11(11):1333–42.doi:10.1093/hmg/11.11.1333.PMID 12019215. StrausbergRL,FeingoldEA,GrouseLH,et al.(2003)."Generationandinitialanalysisofmorethan15,000full-lengthhumanandmousecDNAsequences".Proc.Natl.Acad.Sci.U.S.A.99(26):16899–903.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932. LeGoffMM,HindsonVJ,JowittTA,et al.(2003)."Characterizationofopticinandevidenceofstabledimerizationinsolution".J.Biol.Chem.278(46):45280–7.doi:10.1074/jbc.M303117200.PMID 12951322. RameshS,BonshekRE,BishopPN(2004)."Immunolocalisationofopticininthehumaneye".TheBritishJournalofOphthalmology.88(5):697–702.doi:10.1136/bjo.2003.031989.PMC 1772128.PMID 15090426. GerhardDS,WagnerL,FeingoldEA,et al.(2004)."Thestatus,quality,andexpansionoftheNIHfull-lengthcDNAproject:theMammalianGeneCollection(MGC)".GenomeRes.14(10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334. LiuT,QianWJ,GritsenkoMA,et al.(2006)."HumanplasmaN-glycoproteomeanalysisbyimmunoaffinitysubtraction,hydrazidechemistry,andmassspectrometry".J.ProteomeRes.4(6):2070–80.doi:10.1021/pr0502065.PMC 1850943.PMID 16335952. AcharyaM,MookherjeeS,BhattacharjeeA,et al.(2007)."EvaluationoftheOPTCgeneinprimaryopenangleglaucoma:functionalsignificanceofasilentchange".BMCMol.Biol.8:21.doi:10.1186/1471-2199-8-21.PMC 1838427.PMID 17359525. 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