中興大學生命科學系

最 高 學 歷 ：, 台大醫學院微生物所博士. 專 長 領 域 ：, 癌症生物學、幹細胞生物學、分子細胞生物學. 電 子 信 箱 ：, [email protected]. 實驗室網站： ... 李龍緣[副教授] 辦公室電話： 04-22840416#603 實驗室電話： 04-22840416#603 傳  &nbsp   真 ： 實驗室位置： 生命科學大樓602室 最高學歷 ： 台大醫學院微生物所博士 專長領域 ： 癌症生物學、幹細胞生物學、分子細胞生物學  電子信箱 ： [email protected] 實驗室網站：     學歷 經歷 研究方向 開設課程 研究室人員 學術著作 年份 標題 2012 行政院國家科學委員會吳大猷先生紀念獎 2011 中國醫藥大學系所績優導師 2010 中國醫藥大學醫學院教學優良教師獎 2006 美國癌症研究學會Scholar-in-TrainingAward 2006 美國安德森癌症中心TraineeExcellenceAward 2002 台大醫學院博士班研究生傑出著作獎 2002 第10屆細胞及分子生物新知研討會徐千田優秀論文獎 1995 台灣微生物學會嚴智鍾教授獎學金 1995 劉瑞恆先生紀念獎學金 1992 林公熊徵學田獎學金       癌症訊息傳遞及表觀基因調控、幹細胞分化調控、新藥/新療法研發     A.期刊論文  1.Y-H.Chen,Y-CLiu,C-JChung,S-PYeh,JHsu,M-CHung,H-LSuandL-YLi*.2016/08EZH2andHDAC9cregulateage-dependentmesenchymalstemcelldifferentiationintoosteoblastsandadipocytes.,StemCells.(SCI) 2.Li,C-W.,Xia,W.,Lim,S-O.,Hsu,JenniferL.,Huo,L.,Wu,Y.,Li,L-Y.,Lai,C-C.,Chang,S-S.,Hsu,Y-H.,Sun,H-L.,Kim,J.,Yamaguchi,H.,Lee,D-F.,Wang,H.,Wang,Y.,Chou2016/03AKT1InhibitsEpithelial-to-MesenchymalTransitioninBreastCancerthroughPhosphorylation-DependentTwist1Degradation.,CancerResearch,.vol.76,pp.1451-1462,.(SCI) 3.P-HLin,W-HKuo,A-CHuang,Y-SLu,C-HLin,S-HKuo,M-YWang,C-YLiu,FT-FCheng,M-HYeh,H-YLi,Y-HYang,Y-HHsu,S-CFan,L-YLi,S-LYu,K-JChang,P-LChen,Y-HNi,C-SHuang.2016/02Multiplegenesequencingforriskassessmentinpatientswithearly-onsetorfamilialbreastcancer,Oncotarget,.vol.7,pp.8310-8320.(SCI) 4.KoHW,LeeHH,HuoL,XiaW,YangCC,HsuJL,LiLY,LaiCC,ChanLC,ChengCC,LabaffAM,LiaoHW,LimSO,LiCW,WeiY,NieL,YamaguchiH,HungMC2016GSK3βinactivationpromotestheoncogenicfunctionsofEZH2andenhancesmethylationofH3K27inhumanbreastcancers,Oncotarget.vol.7,pp.57131-57144.(SCI) 5.Dai,H-Y.,Chen,H-Y.,Lai,W-J.,Hung,M-C.,Li,L-Y.*2015/09TargetedexpressionofBikDDcombinedwithmetronomicdoxorubicininducessynergisticantitumoreffectthroughBaxactivationinhepatocellularcarcinoma.,Oncotarget,.vol.6,pp.23807-23819.(SCI) 6.Yang,C-C.,Labaff,A.,Wei,Y.,Nie,L.,Xia,W.,Huo,L.,Yamaguchi,H.,Hsu,Y-H.,Hsu,J.L.,Liu,D.,Lang,J.,Du,Y.,Lien,H-C.,Li,L-Y.,Deng,R.,Chan,L-C.,Yao,J.,Kleer,C.G.,Hortobag2015Phosphorylationofezh2att416bycdk2contributestothemalignancyoftriplenegativebreastcancers.,AmJTranslRes.vol.7,pp.1009-1020.(SCI) 7.Lein,M-Y.,Liu,L-C.,Wang,H-C.,Yeh,M-H.,Chen,C-J.,Yeh,S-P.,Bai,L-Y.,Liao,Y-M.,Lin,C-Y.,Hsieh,C-Y.,Lin,C-C.,Li,L-Y.,Lin,P-H.,Chiu,C-F.2014SafetyandEfficacyofPegylatedLiposomalDoxorubicin-basedAdjuvantChemotherapyinPatientswithStageI-IIITriple-negativeBreastCancer,AnticancerRes..vol.34,pp.7319-7326.(SCI) 8.Su,C-H.,Hsiao,C-L.,Chang,W-S.,Liu,L-C.,Wang,H-C.,Tsai,C-W.,Li,L-Y.,Tsai,C-H.,Bau,D-T.2014Evaluationofthecontributionofcyclooxygenase2genotypestobreastcancerinTaiwan,AnticancerRes..vol.34,pp.6711-6716.(SCI) 9..Liu,Y-C.,Kao,Y-T.,Huang,W-K.,Lin,K-Y.,Wu,S-C.,Hsu,S-C.,Schuyler,S-C.,Li,L-Y.,Lu,L.F.,Lu,J.2014CCL5/RANTESisimportantforinducingosteogenesisofhumanmesenchymalstemcellsandisregulatedbydexamethasone.,BiosciTrends..vol.8,pp.138-143.(SCI) 10.Chang,T-Y.,Chung,C-Y.,Chuang,W-M.,Li,L-Y.,Jeng,L-B.andMa,W-L.2014DurableExpressionofMinicircleDNA-Liposome-deliveredAndrogenReceptorcDNAinMicewithHepatocellularCarcinoma.,BioMedResearchInternational.vol.9,pp.156356.(SCI) 11.Huo,L.,Li,C-W.,Huang,T-H.,Lam,Y.C.,Xia,W.,Tu,C.,Chang,W-C.,Hsu,J.L.,LeeD-F.,Nie,L.,Yamaguchi,H.,Wang,Y.,Lang,J.,Li,L-Y.,Chen,C-H.,Mishra,L.and,Hung,M-C.2014ActivationofKeap1/Nrf2signalingpathwaybynuclearepidermalgrowthfactorreceptorincancercells,AmJTranslRes.vol.6,pp.649-663.(SCI) 12.Chou,R-H.,Wang,Y-N.,Hsieh,Y-H.,Li,L-Y.,Xia,W.,Chang,W-C.,Chang,L-C.,Cheng,C-C.,Lai,C-C.,Hsu,J.L.,Chang,W-J.,Chiang,S-Y.,Lee,H-J.,Liao,H-W.,Chuan2014EGFRmodulatesDNAsynthesisandrepairsthroughTyrphosphorylationofHistoneH4.,DevCell.vol.30,pp.224-237.(SCI) 13.Li,L-Y.*.2014EZH2:noveltherapeutictargetforhumancancer.,BioMedicine,.vol.4,pp.1-6.(SCI) 14.Chang,W-S.,Lin,S-S.,Li,F-J.,Tsai,C-W.,Li,L-Y.,Lien,C-S.,Liao,W-L.,Wu,H-C.Tsai,C-H.,Shih,T-C.,Bau,D-T.,2013SignificantAssociationofCaveolin-1(CAV1)GenotypeswithUpperUrothelialTractCancer.,AnticancerRes..vol.33,pp.4907-4912.(SCI) 15..Lin,P-H.,Lin,C-C.,Yang,H-I.,Li,L-Y.,Bai,L-Y.,Chiu,C-F.,Liao,Y-M.,Lin,C-Y.,Hsieh,C-Y.,Lin,C-Y.,Ho,C-M.,Yang,S-F.,Peng,C-T.,Tsai,F-J.,Yeh,S-P.2013PrognosticimpactofallogeneichematopoieticstemcelltransplantationforacutemyeloidleukemiapatientswithinternaltandemduplicationofFLT3.,LeukemiaResearch,.vol.37,pp.287-292.(SCI) 16.Lin,P-H.,Yeh,M-H.,Liu,L-C.,Chen,C-J.,Tsui,Y-C.,Su,C-H.,Wang,H-C.,Liang,J-A.,Chang,H-W.,Wu,H-S.,*Li,L-Y.andChiu,C-F.2013Clinicalandpathologicriskfactorsoftumorrecurrenceinpatientswithnode-negativeearlybreastcanceraftermastectomy.,JournalofSurgicalOncology,.vol.108,pp.352-7.(SCI) 17.Chen,Y-H.,Hung,M-C.andLi,L-Y.*.2012EZH2:apivotalregulatorincontrollingcelldifferentiation.,AmJTranslRes.vol.4,pp.364-375.(SCI) 18..Liu,M.,Lee,D-F.,Chen,C-T.,Yen,C-J.,Li,L-Y.*,Lee,H-J.,Chang,C-J.,Chang,W-C.,Hsu,J-M.,Kuo,H-P.,Xia,W.,Wei,Y.,Chiu,P-C.,Chou,C-K.,Du,Y.,Dhar,D.,Karin,M.,Chen,C-H.2012IKKαactivationofNOTCHlinkstumorigenesisviaFOXA2suppression.,MolecularCell.vol.45,pp.171-184.(SCI) 19.Song,H.,Li,C-W.,LaBaff,A.M.,Lim,S-O.,Li,L-Y.,Kan,S-F.,Chen,Y.,Zhang,K.,Lang,J-Y.,Xie,X.,Wang,Y.,Huo,L-F.,Hsu,S-C.,Chen,X-M.,Zhao,Y-M.andHungM-C.,2011AcetylationofEGFreceptorcontributestotumorcellresistancetohistonedeacetylaseinhibitors.,Biochem.Biophys.Res.Commun..vol.404,pp.68-73.(SCI) 20.Hsu,J-M.,Chen,C-T.,Chou,C-K.,Kuo,H-P.,Li,L-Y.,Lin,C-Y.,Lee,H-J.,WangY-N.,Liu,M.,Liao,H-W.,Shi,B.,Lai,C-C.,Bedford,M.T.,Tsai,C-H.andHung,M-C.,2011CrosstalkbetweenArg1175methylationandTyr1173phosphorylationnegativelymodulatesEGFR-mediatedERKactivation.,NatureCellBiology.vol.13,pp.174-181.(SCI) 21.Sher,Y-P,Liu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