Somatic epitype - Wikipedia
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A somatic epitype is a non-heritable epigenetic alteration in a gene. It is similar to conventional epigenetics in that it does not involve changes in the ... Somaticepitype FromWikipedia,thefreeencyclopedia Jumptonavigation Jumptosearch Asomaticepitypeisanon-heritableepigeneticalterationinagene.ItissimilartoconventionalepigeneticsinthatitdoesnotinvolvechangesintheDNAprimarysequence.Physically,thesomaticepitypecorrespondstochangesinDNAmethylation,oxidativedamage(replacementofGTPwithoxo-8-dGTP),orchangesinDNA-chromatinstructurethatarenotreversedbynormalcellularornuclearrepairmechanisms.Somaticepitypesaltergeneexpressionlevelswithoutalteringtheaminoacidsequenceoftheexpressedprotein.Currentresearchsuggeststhatsomaticepitypescanbealteredbothbeforeandafterbirth,andthisalterationcanbeinresponsetoexposuretoheavymetals(suchaslead),differencesinmaternalcare,ornutritionalorbehavioralstress.Thereisnoindicationthatsomaticepitypesareheritableinaconventionalepigeneticfashion.Someresearchsuggeststhatmethylationlevels(andgeneexpression)canbereversedforsomesomaticepitypesbyalterationsinenvironmentalfactorssuchasdiet. Seealso[edit] Epigenetics Sources[edit] LahiriDK,MaloneyB(2006)."Genesarenotourdestiny:thesomaticepitypebridgesbetweenthegenotypeandthephenotype".NatureReviewsNeuroscience.7(12):976.doi:10.1038/nrn2022-c1. MathersJC(June2006)."Nutritionalmodulationofageing:genomicandepigeneticapproaches".Mech.AgeingDev.127(6):584–9.doi:10.1016/j.mad.2006.01.018.PMID 16513160.S2CID 9187848. Thisgeneticsarticleisastub.YoucanhelpWikipediabyexpandingit.vte Retrievedfrom"https://en.wikipedia.org/w/index.php?title=Somatic_epitype&oldid=1015155009" Categories:DNAEpigeneticsGeneticsstubsHiddencategories:Allstubarticles Navigationmenu Personaltools NotloggedinTalkContributionsCreateaccountLogin Namespaces ArticleTalk English Views ReadEditViewhistory More Search Navigation MainpageContentsCurrenteventsRandomarticleAboutWikipediaContactusDonate Contribute HelpLearntoeditCommunityportalRecentchangesUploadfile Tools WhatlinkshereRelatedchangesUploadfileSpecialpagesPermanentlinkPageinformationCitethispageWikidataitem Print/export DownloadasPDFPrintableversion Languages Addlinks
延伸文章資訊
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