過敏檢測選項| Allergy & Autoimmune Disease

特異性IgE 檢測，例如特異性IgE 血液檢測及皮膚點刺檢測(SPT)，可作為辨識致敏過敏原的工具，並增加診斷的確定性。

... 特異性IgE 血清檢測有助於診斷過敏疾病。

因此，任何有 ... Areyouahealthcareprofessional? Theinformationinthiswebsiteisintendedonlyforhealthcareprofessionals.Byenteringthissite,youareconfirmingthatyouareahealthcareprofessional. EnterSite ✕ Areyoualaboratoryprofessional? Theinformationinthiswebsiteisintendedonlyforlaboratoryprofessionals.Byenteringthissite,youareconfirmingthatyouarealaboratoryprofessional. EnterSite ✕ Allergy AllergyOverview RespiratoryAllergies RespiratoryAllergiesOverview AllergicRhinitis IndoorAllergies FoodAllergies FoodAllergiesOverview Cow'sMilkAllergy EggAllergy PeanutAllergy TreeNutAllergy FishAllergy ShellfishAllergy WheatAllergy SoyAllergy AtopicDermatitis Urticaria PetAllergy VenomAllergy DrugAllergy LatexAllergy ChronicOtitisMedia Mastocytosis Asthma AutoimmuneDisease AutoimmuneDiseaseOverview AntiphospholipidSyndrome ConnectiveTissueDiseases GastrointestinalDiseases RheumatoidArthritis AutoimmuneThyroidDisease Vasculitis HowtoTest HowtoTestOverview AllergyTestingOptions AutoimmunityTestingOptions ResourceCenter AllergenEncyclopedia ContactUs Home HowtoTest AllergyTestingOptions AllergyTestingOptions Guidedbytheallergy-focusedpatienthistory,themostappropriatenextstepshouldbetestingforallergentriggers. TypesofSpecificIgETests SpecificIgEtestssuchasspecificIgEbloodtestingandskin-pricktests(SPT)canbeleveragedastoolstoidentifysensitizingallergensandincreasediagnosticcertainty.1,2 SpecificIgEserologicaltestsaidinthediagnosisofallergicdisease.Assuch,anyonepresentingwithallergysymptomsisacandidateforspecificIgEtesting.  Whentakingbloodforatest,a1mlsampleofwholebloodisusuallysufficienttotestforupto10differentallergens,althoughhighervolumesofserummayberequiredtotestforlargerallergenprofiles.   Getscientificinformationonmorethan550allergens. AllergenEncyclopedia KeyTestDifferences SpecificIgEBloodTesting Skin-PrickTesting Typicallyorderedandreviewedbyaclinician ✓ ✓ Patientsdonotneedtodiscontinueallergymedications ✓   Requiresonlyoneneedlestick(asinglebloodsample) ✓   Carriesnoriskofsevereallergicreaction ✓   Canbeusedwhenextensiveskinrashispresent ✓   Componenttestingisavailable ✓   Samedayresultsintheoffice   ✓ Wholeallergenandallergencomponents Wholeallergen ImmunoCAP™WholeAllergenprovidesanobjectivemeasurementofthecirculatingIgEantibodiesandthesensitizationtoaspecificallergen.SpecificIgEantibodiesappearasaresultofexposureandfollowingsensitizationtoanallergen.ImmunoCAPWholeAllergenmeasuresIgEantibodiestospecificallergensinhumanserumorplasmaandallowsquantitativemeasurementsofawiderangeofindividualallergensandallergencomponents.Morethan550wholeallergensandmixesareavailablefordeterminations.3 Allergencomponents Often,allergiesarenotasclearcutasasimple“yes”or“no.”That’swherespecificIgEbloodtestingforallergencomponentscomesin.ImmunoCAP™AllergenComponentsmeasurespecificIgEantibodiestoindividualmolecularallergensinserumorplasma.Theseallergens,whicharepurifiedorrecombinantproteins,offertheuniqueopportunitytoassessaperson’sallergicsensitizationpatternatthemolecularlevel.Differentcomponentgroupsoftenelicitdifferenttypesofreactions,sotestingthemcanindicateifapatient’spriorsymptomsorpositivetestresultswerecausedbyallergytoagivensubstanceorbyacross-reactionwithanotherallergen.MeasuringspecificIgEforallergencomponentshelpstheclinicianweighapatient'sriskofasystemicreactionversusamoremildorlocalizedresponse.4   Inshort,allergencomponentshelpclinicians: Differentiatebetweenprimarysensitizationandcross-reactivesensitization Improveassessmentofriskofasystemicreactionversusamoremildorlocalizedresponse Identifyallergensforsuccessfulimmunotherapy(AIT)   More100differentImmunoCAPallergencomponentsareavailablefordeterminations,including: Milk Bosd4(a-lactalbumin) Bosd5(B-lactoglobulin) Bosd6(bovineserumalbumin) Bosd8(casein) Egg Gald1(ovomucoid) Gald2(ovalbumin) Gald3(conalbumin) Gald4(lysozyme) Peanut Arah1,2,3,6(storageproteins) Arah8(PR-10protein) Arah9(lipidtransferprotein) TreeNut Hazelnut Cora1(PR-10protein) Cora8(lipidtransferprotein) Cora9(storageprotein) Cora14(storageprotein) Walnut Jugr1(storageprotein) Jugr3(lipidtransferprotein) BrazilNut Bere1(storageprotein) Cashew Anao3(storageprotein) SymptomThreshold   Upto80percentofpatientswithallergiesaresensitizedtomorethanoneallergen.5Theeffectiscumulative:Anindividualpatientmayhaveanumberoftriggers,which,combined,mayleadtosymptoms.6,7Theallergensymptomthresholdisthepointatwhichthecumulativeallergenloadleadstosymptoms.7 EachpatienthasadifferentlevelofIgEantibodiesatwhichheorshewillshowsymptoms.Untilthesymptomthresholdisreached,thepatientwillnotshowsymptoms.However,whentheseallergensaddup,theyhaveacumulativeeffect,pushingthepatientoverhisorhersymptomthreshold.7Byreducingexposuretocertaintriggers,symptomscanbeavoided.7 Identifyingandreducingexposuretosensitizedallergens,particularlyhousedustmite,canreducetheriskofvirallyinducedasthmaexacerbations.8Inpatientswithasthma,allergiesandrespiratoryviralinfectionsactsynergistically―pushingthepatientovertheirsymptomthreshold―toincreasetheriskofasevereexacerbation.9Patientswithasthmaandallergy,whosubsequentlydeveloparespiratoryviralinfection,areatincreasedriskofhospitaladmission.10 Identifyingalltherelevantsensitizingallergenswillhelpyououtlineacomprehensiveexposurereductionplantokeepyourpatientbelowhisorhersymptomthreshold.  References Duran-Tauleriaetal.Allergy.2004;59(Suppl78):35-41. NiggemannB,NilssonM,FriedrichsF.PediatrAllergyImmunol.2008;19:325-331. PhadiaTMImmunoCAPTMSpecificIgEDirectionsforUseforthePhadia250LaboratorySystem.IssuedSeptember2017. MatricardiP.M.etal.EEACIMolecularAllergologyUser’sGuide.PAI2016;27(suppl123):1-250. Ciprandi G,etal.Eur AnnAllergy Clin Immunol. 2008;40(3):77-83.  EgglestonPA.lmmunol Allergy Clin NorthAm. 2003;23(3):533-547.  Wickman M. Allergy. 2005;60(suppl 79):14-18.  MurrayCS,etal. AmJ Respir Crit careMed. 2017 BusseWW,LemanskeRF,GernJE.TheRoleofViralRespiratoryInfectionsinAsthmaandAsthmaExacerbations.Lancet.2010;376(9743):826834.doi:10.1016/S0140-6736(10)61380-3. GreenRM,CustovicA,SandersonG,HunterJ,JohnstonSL,WoodcockA.Synergismbetweenallergensandvirusesandriskofhospitaladmissionwithasthma:case-controlstudy.BMJ.2002;324:763.[PubMed:11923159]