Sjogren's Syndrome Symptoms - Dry Mouth & Eyes | NIAMS

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Sjögren's syndrome is a chronic (long-lasting) autoimmune disorder that happens when the immune system attacks the glands that make moisture ... Skiptomaincontent NationalInstitutesofHealth ContactUs GetEmailUpdates TopUtilityNav CommunityOutreach Asian-LanguageResources Portalenespañol Sitesearch Menu Breadcrumb Home HealthTopics Sjögren’sSyndrome EnglishEspañol Sjögren’sSyndrome Basics In-DepthRead FacebookTwitterEmailPrintFacebookTwitterEmail DownloadPDF Overview,Symptoms,&Causes Diagnosis,Treatment,&StepstoTake MoreInfo OVERVIEW,SYMPTOMS,&CAUSES Overviewof Sjögren’sSyndrome Sjögren’ssyndromeisachronic(long-lasting)autoimmunedisorderthathappenswhentheimmunesystemattackstheglandsthatmakemoistureintheeyes,mouth,andotherpartsofthebody.Themainsymptomsaredryeyesandmouth,butotherpartsofthebodymaybeaffectedaswell,withmanypeoplereportingfatigueandjointandmusclepain.Inaddition,thediseasecandamagethelungs,kidneys,andnervoussystem.Sjögren’ssyndromepredominantlyaffectswomen. Sjögren’ssyndromecanoccurbyitselforalongsideotherautoimmuneconditionssuchasrheumatoidarthritisorsystemiclupuserythematosus. ThereisnocureforSjögren’ssyndrome,butthereareseveralwaystotreatandmanagethesymptoms. WhoGets Sjögren’sSyndrome? MostpeoplewithSjögren’ssyndromearewomen.Youcangetitatanyage,butitismostcommoninpeopleintheir40sand50s.Itoccursacrossallracialandethnicbackgrounds. Typesof Sjögren’sSyndrome DoctorsdivideSjögren’ssyndromeintotwocategories: Primaryform.Youhavethisformifyoudonothaveanotherrheumaticdisease. Secondaryform.Youhavethisformifyoualsohaveanotherrheumaticdisease,suchas rheumatoidarthritis,systemiclupuserythematosus,scleroderma,orpolymyositis. Symptomsof Sjögren’sSyndrome Sjögren’ssyndromemayhavedifferenteffectsonthebody,andthesymptomsvaryfrompersontoperson.Insomepeople,symptomscyclebetweenmildandsevere. Theclassicsymptomsare: Dryeyes.Youreyesmayburnoritchorfeelliketheyhavesandinthem.Sometimes,thedrynesscausesblurryvisionorsensitivitytobrightlight.Youmaygetirritated,itchyeyelidsduetoinflammation. Drymouth.Yourmouthmayfeelchalky,andyoumayhavetroubleswallowing,speaking,andtasting.Becauseyoulacktheprotectiveeffectsofsaliva,youmaydevelopmoredentaldecay(cavities)andmouthinfections,suchascandidiasis(alsocalledthrush). Insomepeople,themainproblemisdrymouth,whileforothersitisdryeyes,andsomepeopleexperiencebothproblemsequally.Insomecases,Sjögren’ssyndromeaffectsothertissuesandorgansandhasmorewidespreadeffectsonthebody.Theseothereffectsmaycause: Fatigue. Jointpain. Dryskin. Drynasalpassagesandthroat,andadrycough. Skinrashes. Muscleaches. Acidreflux. Vaginaldryness. Swellingoftheglandsaroundthefaceandneck. Troublesleeping. Poorconcentrationandmemoryproblems. Numbness,tingling,andweakness,especiallyintheextremities. Shortnessofbreathortroublebreathing. Muscleweakness. Thesymptomscanbesevere,withsomepeoplereportingdebilitatingpainandfatigue. PeoplewithSjögren’ssyndromehaveahigherchanceofdevelopingatypeofcancercalledlymphoma,buttheriskofdevelopingitislow. Causesof Sjögren’sSyndrome Sjögren’ssyndromeisanautoimmunedisorderthathappenswhentheimmunesystemattackshealthytissues.Normally,theimmunesystemprotectsthebodyfrominfectionanddisease. Researchersdonotknowwhatcausestheimmunesystemtoturnonthebody,buttheybelievethatbothgeneticandenvironmentalfactorsareinvolved.StudieshavelinkedSjögren’ssyndrometovariants(changes)inseveralgenes,manyofwhichareinvolvedinimmunity. InSjögren’ssyndrome,theimmunesystemattackstheglandsthatmaketearsandsaliva.Theresultinginflammationdamagestheglands,limitingtheirproductionofthefluidsthatnormallykeeptheeyesandmouthmoist.Insomecases,theimmunesystemattacksadditionalpartsofthebody,damagingotherorgansandtissuesandcausingarangeofothersymptoms. DownloadPDF Basics JoinaClinicalTrial FIndaClinicalTrial RelatedInformation AutoimmuneDiseases ¿QuéeselsíndromedeSjögren? View/Download/OrderPublications DownloadthistopicasaPDF NewsRelatedtoThisHealthTopic UnderstandingAutoimmuneDiseases NIHNewsinHealth|Jun6,2022 DiscussingBone,Muscle,Skin,&AutoimmuneDiseases:InfoforAmericanIndians,AlaskaNatives-audio SpotlightonResearch|May25,2022 WhatOurProteinsCanTellUsAboutAutoimmuneDiseases NIAMS-RelatedArticle|Mar4,2022 AutoimmuneresponsefoundinmanywithCOVID-19 NIHResearchMatters|Sep30,2021 NIHOffersWeb-BasedTooltoStudyGeneExpressioninHumanNeutrophils Announcement|Aug19,2020 Closetohome:NIHresearcherandalopeciapatientseeksacure NIHMedlinePlus|Sep4,2019 FacebookTwitterEmailPrintFacebookTwitterEmail LastReviewed: January2021 BacktoTop



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