Bio-optimized Curcuma longa extract is efficient on knee ...
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Two recent meta-analyses evaluating a large number of dietary supplements ranked curcumin as one of the most effective compounds for pain ... Skiptomaincontent Advertisement SearchallBMCarticles Search DownloadPDF Researcharticle OpenAccess Published:27July2019 Bio-optimizedCurcumalongaextractisefficientonkneeosteoarthritispain:adouble-blindmulticenterrandomizedplacebocontrolledthree-armstudy Y.Henrotin ORCID:orcid.org/0000-0002-2846-43981,2,3,M.Malaise4,R.Wittoek5,K.deVlam6,J.-P.Brasseur7,F.P.Luyten8,Q.Jiangang9,M.VandenBerghe10,R.Uhoda11,J.Bentin12,T.DeVroey13,L.Erpicum14,A.F.Donneau15&Y.Dierckxsens16 ArthritisResearch&Therapy volume 21,Article number: 179(2019) Citethisarticle 8347Accesses 26Citations 6Altmetric Metricsdetails ALettertothisarticlewaspublishedon11February2020 AbstractObjectivesComparisonoftwodosesofbio-optimizedCurcumalongaextract(BCL)inthemanagementofsymptomatickneeosteoarthritis(OA).MethodsAprospective,randomized,3-month,double-blind,multicenter,three-group,placebo-controlledtrialassessingPatientGlobalAssessmentofDiseaseActivity(PGADA)andserumsColl2-1,abiomarkerofcartilagedegradation,asco-primaryendpoints.Painonvisualanalogscale(VAS),KneeinjuryandOsteoarthritisOutcomeScore(KOOS),andparacetamol/non-steroidalanti-inflammatorydrug(NSAID)consumptionwereusedassecondaryendpoints.ResultsOnehundredfiftypatientswithkneeOAwerefollowedfor90 days.LowandhighdosesofBCLshowedagreaterdecreaseofPGADAthanplacebo.AnalysisofsColl2-1showedintheplaceboandBCLlow-dosegroups,butnotintheBCLhigh-dosegroup,atransientbutnon-significantincreaseofsColl2-1betweenT0andT1.Thereafter,inallgroups,sColl2-1decreasedbetweenT1andT3(allp 80%inallgroupsandcomparableintheplaceboandBCLgroups,demonstratingexcellentcompliance.ThiswasconfirmedbycurcuminmeasurementinPP.CurcuminserumlevelsdramaticallyincreasedatT1(p
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